{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:10:04Z","timestamp":1777039804233,"version":"3.51.4"},"reference-count":21,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Affiliated Hospital of Guangdong Medical University Clinical Research","award":["LCYJ2020A001"],"award-info":[{"award-number":["LCYJ2020A001"]}]},{"name":"Guangdong Medical University","award":["4SG21276P"],"award-info":[{"award-number":["4SG21276P"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,14]]},"abstract":"Abstract<\/jats:title>\n \n Context<\/jats:title>\n Hemichorea associated with nonketotic hyperglycemia (HC-NH) is a rare diabetic complication for which the pathogenesis remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study reported 16 cases of HC-NH to improve the understanding of the disease and avoid misdiagnosis and missed diagnosis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Data of 16 patients with HC-NH in a single center from 2000 to 2021 were analyzed retrospectively, and the relevant literature was reviewed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The participants (8 men and 8 women) had a mean age of 67.6 \u00b1 16.4 years. Bilateral limbs were involved in 2 cases, and the others had hemichorea (6 in the left side and 8 in the right side). The average random blood glucose level was 17.51 \u00b1 7.67 mmol\/L, and the glycated hemoglobin A1c level was 11.9%\u00b13.1% at admission. Eleven patients had a history of diabetes, and the other 5 patients were diagnosed with new-onset diabetes mellitus, but no remarkable differences were observed in the presentation or treatment of chorea. Ketonuria was detected in 7 patients. The basal ganglia (putamen, globus pallidus, and caudate nucleus) of 9 cases had typical hyperdensity on computed tomography and\/or hyperintensity signals from magnetic resonance imaging. The chorea symptoms of 15 patients improved within 5.0 \u00b1 1.9 days after treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This study provides additional valuable information about the clinical and neuroimaging features of HC-NH. We hypothesize that chronic ischemia of the basal ganglia due to cerebral atherosclerosis combined with hyperglycemia is associated with HC-NH.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/clinem\/dgad077","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T17:29:38Z","timestamp":1676654978000},"page":"e550-e556","source":"Crossref","is-referenced-by-count":4,"title":["Hemichorea Associated With Nonketotic Hyperglycemia"],"prefix":"10.1210","volume":"108","author":[{"given":"Xiaoming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Guangdong Medical University , Zhanjiang, 524001 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choudi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Guangdong Medical University , Zhanjiang, 524001 , 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