{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:56Z","timestamp":1787021276714,"version":"build-2736575974"},"reference-count":44,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza University of Rome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Suppression of bone turnover, greater trabecular volume, and normal-high normal all-site bone mineral density (BMD) are hallmarks of postsurgical hypoparathyroidism (HypoPT). Impairment in the trabecular microarchitecture with possible higher risk of vertebral fractures (VF) in women with postmenopausal HypoPT has also been described. Currently, no data on bone marrow adipose tissue (BMAT) are available in HypoPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess BMAT by magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS) in postmenopausal women with chronic postsurgical HypoPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional pilot study, conducted at an ambulatory referral center, included 29 postmenopausal women (mean age 66 \u00b1 8.4 years) with postsurgical HypoPT and 31 healthy postmenopausal women (mean age 63 \u00b1 8.5). Lumbar spine MRI was performed and BMAT was measured by applying PRESS sequences on the L3 body. Lumbar spine, femoral neck, and total hip BMD were measured by dual x-ray absorptiometry (DXA); site-matched spine trabecular bone score (TBS) was calculated by TBS iNsight (Medimaps, Switzerland); VF assessment was performed with lateral thoracic and lumbar spine DXA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fat content (FC) and saturation level (SL%) were higher (P &amp;lt;.0001 and P &amp;lt;.001), while water content (W) was lower in HypoPT compared to controls (P &amp;lt;.0001). FC significantly correlated with years since menopause and body weight (P &amp;lt;.05) in HypoPT, while TBS negatively correlated with FC and SL% (P &amp;lt;.05) and positively with residual lipids (RL) and W (P &amp;lt;.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We demonstrate for the first time that BMAT is increased in postmenopausal women with postsurgical hypoparathyroidism and negatively associated with trabecular microarchitecture.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgad116","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T11:06:47Z","timestamp":1677668807000},"page":"e807-e815","source":"Crossref","is-referenced-by-count":9,"title":["Bone Marrow Adipose Tissue Is Increased in Postmenopausal Women With Postsurgical 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