{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:06:22Z","timestamp":1792760782770,"version":"4.5.0"},"reference-count":46,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Imaging plays an important role in the characterization of adrenal tumors, but findings might be inconclusive. The clinical question is whether 18F fluodeoxyglucose (18F-FDG) positron emission tomography\/computed tomography (PET\/CT) is of diagnostic value in this setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This meta-analysis was aimed at the diagnostic value of 18F-FDG PET\/CT in differentiating benign from malignant adrenal tumors discovered either as adrenal incidentaloma or during staging or follow-up of oncologic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data sources<\/jats:title><jats:p>PubMed, EMBASE, Web of Science, and Cochrane Library were searched to select articles between 2000 and 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study selection<\/jats:title><jats:p>We included studies describing the diagnostic value of 18F-FDG PET\/CT in adult patients with an adrenal tumor. Exclusion criteria were 10 or fewer participants, insufficient data on histopathology, clinical follow-up, or PET results. After screening of title and abstract by 2 independent reviewers, 79 studies were retrieved, of which 17 studies met the selection criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data extraction<\/jats:title><jats:p>Data extraction using a protocol and quality assessment according to QUADAS-2 was performed independently by at least 2 authors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data synthesis<\/jats:title><jats:p>A bivariate random-effects model was applied using R (version 3.6.2.). Pooled sensitivity and specificity of 18F-FDG PET\/CT for identifying malignant adrenal tumors was 87.3% (95% CI, 82.5%-90.9%) and 84.7% (95% CI, 79.3%-88.9%), respectively. The pooled diagnostic odds ratio was 9.20 (95% CI, 5.27-16.08; P &amp;lt; .01). Major sources of heterogeneity (I2, 57.1% [95% CI, 27.5%-74.6%]) were in population characteristics, reference standard, and interpretation criteria of imaging results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>18F-FDG PET\/CT had good diagnostic accuracy for characterization of adrenal tumors. The literature, however, is limited, in particular regarding adrenal incidentalomas. Large prospective studies in well-defined patient populations with application of validated cutoff values are needed.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgad138","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T01:29:20Z","timestamp":1679534960000},"page":"2435-2445","source":"Crossref","is-referenced-by-count":21,"title":["The Diagnostic Value of 18F-FDG PET\/CT Scan in Characterizing Adrenal Tumors"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-394X","authenticated-orcid":false,"given":"Merit","family":"Schaafsma","sequence":"first","affiliation":[{"name":"Department of Endocrinology, University of Groningen, University Medical Center Groningen , Groningen 9713GZ , Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika M A","family":"Berends","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Groningen, University Medical 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