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This is due to the lack of large, long-term testosterone therapy trials assessing definitive clinical endpoints. However, men \u226550 years of age, particularly those who have a body mass index &amp;gt;25 kg\/m2 and multiple comorbidities, commonly present with clinical features of androgen deficiency and low serum testosterone concentrations. Clinicians are faced with the question whether to initiate testosterone therapy, a difficult dilemma that entails a benefit-risk analysis with limited evidence from clinical trials. Using a case scenario, we present a practical approach to the clinical assessment and management of such men.<\/jats:p>","DOI":"10.1210\/clinem\/dgad180","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:30:13Z","timestamp":1680222613000},"page":"e871-e884","source":"Crossref","is-referenced-by-count":24,"title":["Approach to the Patient: The Evaluation and Management of Men \u226550 Years With Low Serum Testosterone Concentration"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-3457","authenticated-orcid":false,"given":"Mathis","family":"Grossmann","sequence":"first","affiliation":[{"name":"Department of Medicine (Austin Health), The University of Melbourne , Melbourne, Victoria 3084 , Australia"},{"name":"Department of Endocrinology, Austin Health , Heidelberg, Victoria 3084 , 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