{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T19:26:06Z","timestamp":1787685966979,"version":"build-2784847793"},"reference-count":35,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University People\u2019s Hospital Research and Development","doi-asserted-by":"publisher","award":["RDX2019-12"],"award-info":[{"award-number":["RDX2019-12"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Challenges exist in the management of Glucokinase\u2013maturity-onset diabetes of the young (GCK-MODY), especially during pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to evaluate the prevalence of congenital anomaly in newborns from GCK-MODY mothers, and the relationship between fetus genotype and the risk of congenital malformation as well as other adverse pregnancy outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Electronic databases including PubMed, EMBASE, and Cochrane database last updated July 16, 2022, were searched. We included observational studies conducted in GCK-MODY complicated by pregnancy, and reporting at least one pregnancy outcome. We extracted data in duplicate, and the risk of bias was evaluated by the Newcastle-Ottawa Quality Assessment Scale (NOS). All statistical analysis was performed by Cochrane Review Manager.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eight studies were selected in the meta-analysis. Five were of high quality and 3 were of medium quality evaluated by NOS. A total of 257 GCK-MODY mothers and 499 offspring were enrolled. Among them, 370 offspring were divided into 2 groups: GCK-affected offspring (GCK+, n = 238) and GCK-unaffected offspring (GCK\u2212, n = 132). The percentage of congenital malformations in GCK pregnant women's offspring was 2.4%. The risk of congenital malformations was similar between the GCK+ and GCK\u2212 group (odds ratio = 0.56; 95% CI, 0.07-4.51; I2 = 0%; P = .59). The risk of macrosomia\/large for gestational age, neonatal hypoglycemia, and combined adverse neonatal outcome was significantly lower in offspring with the GCK mutation compared with non\u2013GCK mutation carriers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The percentage of congenital malformations was 2.4% in GCK-MODY pregnant women's offspring, and newborns with the GCK mutation have lower birth complication than non\u2013GCK mutation carriers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad188","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T19:11:16Z","timestamp":1680549076000},"page":"2739-2746","source":"Crossref","is-referenced-by-count":10,"title":["Maternal and Infant Outcomes in GCK-MODY Complicated by Pregnancy"],"prefix":"10.1210","volume":"108","author":[{"given":"Qian","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People's Hospital , Xicheng District, Beijing 100044 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People's Hospital , Xicheng District, Beijing 100044 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People's Hospital , Xicheng District, Beijing 100044 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People's Hospital , Xicheng District, Beijing 100044 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-2168","authenticated-orcid":false,"given":"Linong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Peking University People's Hospital , Xicheng District, Beijing 100044 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"issue":"8805","key":"2023091800465745800_dgad188-B1","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/0140-6736(92)91958-B","article-title":"Linkage of type 2 diabetes to the glucokinase gene","volume":"339","author":"Hattersley","year":"1992","journal-title":"Lancet"},{"issue":"6371","key":"2023091800465745800_dgad188-B2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/356721a0","article-title":"Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus","volume":"356","author":"Vionnet","year":"1992","journal-title":"Nature"},{"issue":"6365","key":"2023091800465745800_dgad188-B3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/356162a0","article-title":"Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus [published correction appears in Nature. 1992;357(6379):607]","volume":"356","author":"Froguel","year":"1992","journal-title":"Nature"},{"issue":"10","key":"2023091800465745800_dgad188-B4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1056\/NEJM199303113281005","article-title":"Familial hyperglycemia due to mutations in glucokinase. 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