{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:40:29Z","timestamp":1782837629271,"version":"3.54.5"},"reference-count":31,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004196","name":"Odense University Hospital Fund","doi-asserted-by":"publisher","award":["A4599"],"award-info":[{"award-number":["A4599"]}],"id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Congenital combined pituitary hormone deficiency (cCPHD) is the loss of \u22652 pituitary hormones caused by congenital factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to estimate the national incidence of cCPHD diagnosed before age 18 years and in subgroups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with cCPHD were identified in the Danish National Patient Registry and Danish hospital registries in the period 1996-2020. Hospital files were reviewed and incidences calculated using background population data. Incidence was the main outcome measure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 128 patients with cCPHD; 88 (68.8%) were males. The median (range) age at diagnosis was 6.2 (0.01-19.0) years. The median (25th;75th percentile) number of hormone deficiencies at diagnosis was 3 (3; 4) at &amp;lt;1 year vs 2 (2; 2) at 1-17 years, P &amp;lt; .0001. Abnormal pituitary magnetic resonance imaging findings were seen in 70.3% (83\/118). For those born in Denmark aged &amp;lt;18 years at diagnosis (n = 116\/128) the estimated national incidence (95% CI) of cCPHD was 10.34 (7.79-13.72) per 100 000 births, with an annual incidence rate of 5.74 (4.33-7.62) per million. In subgroup analysis (diagnosis &amp;lt;1 vs 1-17 years), the incidence was highest in the 1-17 years subgroup, 7.97 (5.77-11.00) vs 1.98 (1.39-2.84) per 100 000 births, whereas the annual incidence rate was highest at &amp;lt;1 year, 19.8 (13.9-28.4) vs 4.69 (3.39-6.47) per million births.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>cCPHD had the highest incidence rate and the most hormone deficiencies in those diagnosed at &amp;lt;1 year. The incidence was highest in the 1-17 years age group, underscoring the need for multiple pituitary hormone investigations throughout childhood and adolescence in children with only 1 hormone deficiency.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad198","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T17:36:42Z","timestamp":1681321002000},"page":"2475-2485","source":"Crossref","is-referenced-by-count":9,"title":["Diagnosis and Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark\u2014A National Observational Study"],"prefix":"10.1210","volume":"108","author":[{"given":"Louise Kjersgaard","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital , 5000 Odense , Denmark"},{"name":"OPEN, Open Patient data Explorative Network, Odense University Hospital , 5000 Odense , 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Hospital, Odense University Hospital , 5000 Odense , Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Margrethe R\u00f8nholt","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Aalborg University Hospital , 9000 Aalborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja Carsting","family":"Bjerrum","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital , 5000 Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-6853","authenticated-orcid":false,"given":"Henrik Thybo","family":"Christesen","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital , 5000 Odense , Denmark"},{"name":"OPEN, Open 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