{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:40:08Z","timestamp":1791819608554,"version":"4.3.4"},"reference-count":29,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NHS Tayside Research Endowments"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Previous studies, including our own, have demonstrated a highly variable incidence of primary hyperparathyroidism (PHPT) from year to year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We planned to provide a current estimate of the incidence and prevalence of PHPT in a community-based study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A population-based retrospective follow-up study was conducted in Tayside (Scotland) from 2007 to 2018. Record-linkage technology (demography, biochemistry, prescribing, hospital admissions, radiology, and mortality data) was used to identify all patients. Cases of PHPT were defined as those with at least 2 raised serum corrected calcium concentration CCA (&amp;gt; 2.55 mmol\/L) and\/or hospital admissions with PHPT diagnoses and\/or surgery records with parathyroidectomy during the follow-up period. The number of prevalent and incident cases of PHPT per calendar year by age and sex were estimated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2118 people (72.3% female, mean age 65 years) were identified with an incident case of PHPT. The overall prevalence of PHPT over the 12 years of the study was 0.84% (95% CI, 0.68%-1.02%), steadily increasing from 0.71% in 2007 to 1.02% in 2018. From 2008, the incidence of PHPT was relatively stable from 4 to 6 cases per 10 000 person-years, declining from 11.5 per 10 000 person-years in 2007. The incidence varied from 0.59 per 10 000 person-years (95% CI, 0.40%-0.77%) for those aged 20 to 29 years, to 12.4 per 10 000 person-years (95% CI, 11.2%-13.3%) in those aged 70 to 79 years. Incidence of PHPT was 2.5 times higher in women than in men.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study is the first showing a relatively steady annual incidence of PHPT at 4 to 6 per 10 000 person-years. This population-based study reports a PHPT prevalence of 0.84%.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad201","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T17:04:04Z","timestamp":1680800644000},"page":"e1117-e1124","source":"Crossref","is-referenced-by-count":56,"title":["Stable Incidence and Increasing Prevalence of Primary Hyperparathyroidism in a Population-based Study in Scotland"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-5301","authenticated-orcid":false,"given":"Enrique","family":"Soto-Pedre","sequence":"first","affiliation":[{"name":"Division of Population Health and Genomics, School of Medicine, Ninewells Hospital and Medical School, University of Dundee , Dundee DD1 9SY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Newey","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Ninewells Hospital and Medical School, University of Dundee , Dundee DD1 9SY , UK"},{"name":"Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee , Dundee DD1 9SY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham P","family":"Leese","sequence":"additional","affiliation":[{"name":"Division of Population Health and Genomics, School of Medicine, Ninewells Hospital and Medical School, University of Dundee , Dundee DD1 9SY , UK"},{"name":"Department of Endocrinology and Diabetes, Ninewells Hospital and Medical School, University of Dundee , Dundee DD1 9SY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,4,6]]},"reference":[{"key":"2023091800464336400_dgad201-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bone.2014.12.003","article-title":"Secular trends in the incidence of primary hyperparathyroidism over five decades (1965-2010)","volume":"73","author":"Griebeler","year":"2015","journal-title":"Bone"},{"issue":"4","key":"2023091800464336400_dgad201-B2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2265.2008.03520.x","article-title":"Epidemiology of primary hyperparathyroidism in Tayside, Scotland, UK","volume":"71","author":"Yu","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"2023091800464336400_dgad201-B3","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1210\/jc.2012-4022","article-title":"Incidence and prevalence of primary hyperparathyroidism in a racially mixed population","volume":"98","author":"Yeh","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2023091800464336400_dgad201-B4","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.surg.2013.06.051","article-title":"The prevalence of undiagnosed and unrecognized primary hyperparathyroidism: a population-based analysis from the electronic medical record","volume":"154","author":"Press","year":"2013","journal-title":"Surgery"},{"issue":"5","key":"2023091800464336400_dgad201-B5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4174\/astr.2018.94.5.235","article-title":"The prevalence of primary hyperparathyroidism in Korea: a population-based analysis from patient medical records","volume":"94","author":"Kim","year":"2018","journal-title":"Ann Surg Treat Res"},{"issue":"4","key":"2023091800464336400_dgad201-B6","first-page":"257","article-title":"Prevalence and incidence of primary hyperparathyroidism in Bahrain: a retrospective study from one medical center","volume":"42","author":"Abdulla","year":"2021","journal-title":"Neuro Endocrinol Lett"},{"issue":"1","key":"2023091800464336400_dgad201-B7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1359\/JBMR.050910","article-title":"Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993-2001: an update on the changing epidemiology of the disease","volume":"21","author":"Wermers","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2023091800464336400_dgad201-B8","first-page":"A4567","article-title":"Increasing incidence of primary hyperparathyroidism in Denmark","volume":"60","author":"Abood","year":"2013","journal-title":"Dan Med J"},{"issue":"3","key":"2023091800464336400_dgad201-B9","doi-asserted-by":"crossref","first-page":"e0230130","DOI":"10.1371\/journal.pone.0230130","article-title":"Epidemiology and management of parathyroid gland disorders in Spain over 15 years: a retrospective multicentre analysis","volume":"15","author":"Darb\u00e0","year":"2020","journal-title":"PLoS One"},{"key":"2023091800464336400_dgad201-B10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.clinbiochem.2022.12.015","article-title":"Calcium requests in a primary care; 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