{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:03:37Z","timestamp":1791374617217,"version":"4.3.1"},"reference-count":102,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T00:00:00Z","timestamp":1680912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Accelerated early growth and early timing of puberty or pubertal variant have been noticed as risk factors for metabolic syndrome, more frequently observed in children born small for gestational age (SGA) or children with premature adrenarche (PA). Children with SGA, especially if they make an accelerated catch-up growth in early life, carry a higher risk for long-term metabolic consequences, such as type 2 diabetes, insulin resistance, and cardiovascular diseases. Furthermore, multiple studies support that these children, either born SGA or with a history of PA, may have earlier pubertal timing, which is also associated with various metabolic risks. This review aims to summarize the recent studies investigating the association between early infantile growth, the timing of puberty, and metabolic risks to expand our knowledge and gain more insight into the underlying pathophysiology.<\/jats:p>","DOI":"10.1210\/clinem\/dgad202","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T17:26:45Z","timestamp":1680974805000},"page":"e663-e670","source":"Crossref","is-referenced-by-count":29,"title":["The Association of Accelerated Early Growth, Timing of Puberty, and Metabolic Consequences in Children"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7227-5925","authenticated-orcid":false,"given":"Youn Hee","family":"Jee","sequence":"first","affiliation":[{"name":"Section on Growth, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA"},{"name":"Division of Endocrinology and Center for Genetic Medicine Research, Children's National Hospital, Washington, DC 20010, USA"},{"name":"Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20012, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-6642","authenticated-orcid":false,"given":"Sanjay","family":"Jumani","sequence":"additional","affiliation":[{"name":"Section on Growth, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2287-0181","authenticated-orcid":false,"given":"Veronica","family":"Mericq","sequence":"additional","affiliation":[{"name":"Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago 13101, 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