{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:57:40Z","timestamp":1793411860690,"version":"4.5.0"},"reference-count":60,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different etiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This nationwide, multicenter, retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either COVID-19\u2013related SAT (Cov-SAT), SARS-CoV-2 vaccine\u2013related SAT (Vac-SAT), or control SAT (Cont-SAT) groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 811 patients, 258 (31.8%) were included in the Vac-SAT group, 98 (12.1%) in the Cov-SAT group, and 455 (56.1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. SAT etiology was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT etiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Since there is no difference in terms of follow-up parameters and outcomes, COVID-19\u2013 and SARS-CoV-2 vaccine\u2013related SAT can be treated and followed up like classic SATs. Recurrence was determined by younger age and steroid therapy requirement. Steroid therapy independently predicts incident hypothyroidism that may sometimes be transient in overall SAT and is also associated with a lower risk of established hypothyroidism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad235","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:31:17Z","timestamp":1682469077000},"page":"e1013-e1026","source":"Crossref","is-referenced-by-count":17,"title":["Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0933-6198","authenticated-orcid":false,"given":"Adnan","family":"Batman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, School of Medicine, Koc University , 34010 Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-0004","authenticated-orcid":false,"given":"Dilek","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Metabolism, School of Medicine, Koc University , 34010 Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuz","family":"Dikba\u015f","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Giresun University School of Medicine , 28200 Giresun , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3122-5491","authenticated-orcid":false,"given":"Kemal","family":"A\u011fbaht","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Defne Hospital , 31030 Hatay , 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Statistics Beytepe, Hacettepe University , 06230 Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-5750","authenticated-orcid":false,"given":"G\u00f6rkem","family":"Ayas","sequence":"additional","affiliation":[{"name":"School of Medicine, Koc University , 34450 Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-9733","authenticated-orcid":false,"given":"C\u00fcneyd","family":"An\u0131l","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, G\u00fcven Hospital , 06540 Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-2604","authenticated-orcid":false,"given":"Mustafa","family":"Cesur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, G\u00fcven Hospital , 06540 Ankara , 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