{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:16:26Z","timestamp":1788383786050,"version":"build-2803163510"},"reference-count":39,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acromegaly is a chronic condition caused by the excessive production of growth hormone and is characterized by progressive morphological and systemic complications, as well as increased prevalence of psychopathologies, which markedly affect patients\u2019 quality of life. The advancing multimodal therapies, while significantly improving the morbidity and mortality, have limited impact on psychopathologies, which often persist despite disease remission. The most common psychopathologies in acromegaly include depression, anxiety and affective disorders, together with sexual dysfunction, which may be considered as either a consequence or potentially even a contributory factor to these psychopathologies. Approximately one-third of patients with acromegaly manifest depression, whereas two-thirds of patients display anxiety, with both conditions tending to be more prevalent and severe in younger patients with shorter duration of disease. Apparently, a major impact of psychological discomfort in women compared with men appears to be the fact that women tend to internalize whereas men tend to externalize their distress. Personality disorders also commonly associated with acromegaly, especially due to body image suffering, are linked to sexual dysfunction, which seems to affect women more than men. In summary, psychopathology in acromegaly is a major determinant of the quality of life and a complex array of psychological abnormalities are associated with acromegaly.<\/jats:p>","DOI":"10.1210\/clinem\/dgad237","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T07:38:35Z","timestamp":1683185915000},"page":"2470-2474","source":"Crossref","is-referenced-by-count":8,"title":["Psychopathology in Acromegaly\u2014Real and Perceived"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9632-1348","authenticated-orcid":false,"given":"Rosario","family":"Pivonello","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Diabetologia, Andrologia e Nutrizione, Universit\u00e0 Federico II di Napoli , Naples 80131 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian J C M M","family":"Neggers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Endocrinology, Erasmus University Medical Center Rotterdam , Rotterdam 3015GD , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Ali","family":"Imran","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Dalhousie University , Halifax, NS B3H 2Y9 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"2023091800472395700_dgad237-B1","first-page":"297","article-title":"Sur deux cas d\u2019acrome\u0301galie; hypertrophie singulie\u0300re non conge\u0301nitale des extre\u0301mite\u0301s supe\u0301rieures, infe\u0301rieures et ce\u0301phalique","volume":"6","author":"Marie","year":"1886","journal-title":"Rev M\u00e9d Li\u00e8ge"},{"key":"2023091800472395700_dgad237-B2","first-page":"7","article-title":"Medicarum observationum. 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