{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:57:28Z","timestamp":1787954248372,"version":"build-2784847793"},"reference-count":54,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Hungarian Hypertension Society"},{"name":"Dean of the Medical Faculty, Semmelweis University"},{"name":"Semmelweis Science and Innovation Fund","award":["STIA-OTKA-2021"],"award-info":[{"award-number":["STIA-OTKA-2021"]}]},{"name":"Semmelweis Science and Innovation Fund","award":["OTKA-PD 113022"],"award-info":[{"award-number":["OTKA-PD 113022"]}]},{"name":"Semmelweis Science and Innovation Fund","award":["NKFIH-FK 129206"],"award-info":[{"award-number":["NKFIH-FK 129206"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>There is no early, first-trimester risk estimation available to predict later (gestational week 24-28) gestational diabetes mellitus (GDM); however, it would be beneficial to start an early treatment to prevent the development of complications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to identify early, first-trimester prediction markers for GDM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The present case\u2013control study is based on the study cohort of a Hungarian biobank containing biological samples and follow-up data from 2545 pregnant women. Oxidative\u2013nitrative stress-related parameters, steroid hormone, and metabolite levels were measured in the serum\/plasma samples collected at the end of the first trimester from 55 randomly selected control and 55 women who developed GDM later.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Pregnant women who developed GDM later during the pregnancy were older and had higher body mass index. The following parameters showed higher concentration in their serum\/plasma samples: fructosamine, total antioxidant capacity, testosterone, cortisone, 21-deoxycortisol; soluble urokinase plasminogen activator receptor, dehydroepiandrosterone sulfate, dihydrotestosterone, cortisol, and 11-deoxycorticosterone levels were lower. Analyzing these variables using a forward stepwise multivariate logistic regression model, we established a GDM prediction model with a specificity of 96.6% and sensitivity of 97.5% (included variables: fructosamine, cortisol, cortisone, 11-deoxycorticosterone, SuPAR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Based on these measurements, we accurately predict the development of later-onset GDM (24th-28th weeks of pregnancy). Early risk estimation provides the opportunity for targeted prevention and the timely treatment of GDM. Prevention and slowing the progression of GDM result in a lower lifelong metabolic risk for both mother and offspring.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad301","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T18:25:01Z","timestamp":1685384701000},"page":"e1214-e1223","source":"Crossref","is-referenced-by-count":18,"title":["Risk Estimation of Gestational Diabetes Mellitus in the First Trimester"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9883-7367","authenticated-orcid":false,"given":"D\u00f3ra","family":"Gerszi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University , Budapest H-1082 , Hungary"},{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University , Budapest H-1094 , 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