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NAFLD is a progressive disease without effective treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We hypothesized that GH administration would reduce hepatic steatosis in individuals with overweight\/obesity and NAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this 6-month randomized, double-blind, placebo-controlled trial of low-dose GH administration, 53 adults aged 18 to 65 years with BMI \u226525 kg\/m2 and NAFLD without diabetes were randomized to daily subcutaneous GH or placebo, targeting insulin-like growth factor 1 (IGF-1) to the upper normal quartile. The primary endpoint was intrahepatic lipid content (IHL) by proton magnetic resonance spectroscopy (1H-MRS) assessed before treatment and at 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subjects were randomly assigned to a treatment group (27 GH; 26 placebo), with 41 completers (20 GH and 21 placebo) at 6 months. Reduction in absolute % IHL by 1H-MRS was significantly greater in the GH vs placebo group (mean \u00b1 SD: \u22125.2 \u00b1 10.5% vs 3.8 \u00b1 6.9%; P = .009), resulting in a net mean treatment effect of \u22128.9% (95% CI, \u221214.5 to \u22123.3%). All side effects were similar between groups, except for non-clinically significant lower extremity edema, which was more frequent in the GH vs placebo group (21% vs 0%, P = .02). There were no study discontinuations due to worsening of glycemic status, and there were no significant differences in change in glycemic measures or insulin resistance between the GH and placebo groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GH administration reduces hepatic steatosis in adults with overweight\/obesity and NAFLD without worsening glycemic measures. The GH\/IGF-1 axis may lead to future therapeutic targets for NAFLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgad375","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T22:34:19Z","timestamp":1687818859000},"page":"e1542-e1550","source":"Crossref","is-referenced-by-count":35,"title":["Growth Hormone Administration Improves Nonalcoholic Fatty Liver Disease in Overweight\/Obesity: A Randomized Trial"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6989-2308","authenticated-orcid":false,"given":"Laura E","family":"Dichtel","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E","family":"Corey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie S","family":"Haines","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L","family":"Chicote","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Lee","sequence":"additional","affiliation":[{"name":"Biostatistics Center, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Kimball","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Colling","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey G","family":"Simon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle T","family":"Long","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine , Boston, MA 02118 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jad","family":"Husseini","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam A","family":"Bredella","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen K","family":"Miller","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital\/Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"issue":"6","key":"2023111712364152900_dgad375-B1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/ajg.2012.128","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association","volume":"107","author":"Chalasani","year":"2012","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"2023111712364152900_dgad375-B2","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/jgh.13264","article-title":"Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. 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