{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:58:22Z","timestamp":1784883502114,"version":"3.55.0"},"reference-count":24,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24DK109940"],"award-info":[{"award-number":["K24DK109940"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK103946"],"award-info":[{"award-number":["R01 DK103946"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK110419"],"award-info":[{"award-number":["K23DK110419"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24HD071843"],"award-info":[{"award-number":["K24HD071843"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK057521"],"award-info":[{"award-number":["P30DK057521"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Obesity is associated with nonalcoholic fatty liver disease (NAFLD). Sleeve gastrectomy (SG) is an effective means of weight loss and improvement of NAFLD in adults; however, data regarding the efficacy of SG in the early stages of pediatric NAFLD are sparse.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess the impact of SG on hepatic fat content 1 year after SG in youth with obesity compared with nonsurgical controls with obesity (NS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A 12-month prospective study in 52 participants (mean age, 18.2 \u00b1 .36 years) with obesity, comprising 25 subjects who underwent SG (84% female; median body mass index [BMI], 44.6 [42.1-47.9] kg\/m2) and 27 who were NS (70% female; median BMI, 42.2 [38.7-47.0] kg\/m2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Hepatic fat content by computed tomography (liver\/spleen ratio), abdominal fat by magnetic resonance imaging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean 12-month decrease in BMI was greater in SG vs NS (\u221212.5 \u00b1 .8 vs \u2212.2 \u00b1 .5 kg\/m2, P &amp;lt; .0001). There was a within-group increase in the liver-to-spleen (L\/S) ratio in SG (.13 \u00b1 .05, P = .014) but not NS with a trend for a difference between groups (P = .055). All SG participants with an L\/S ratio &amp;lt;1.0 (threshold for the diagnosis of NAFLD) before surgery had a ratio of &amp;gt;1.0 a year after surgery, consistent with resolution of NAFLD. Within SG, the 12-month change in L\/S ratio was negatively associated with 12-month change in visceral fat (\u03c1 = \u2212.51 P = .016).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Hepatic fat content as assessed by noncontrast computed tomography improved after SG over 1 year in youth with obesity with resolution of NAFLD in all subjects. This was associated with decreases in visceral adiposity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad390","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T04:02:49Z","timestamp":1688529769000},"page":"e1489-e1495","source":"Crossref","is-referenced-by-count":12,"title":["Changes in Hepatic Fat Content by CT 1 Year After Sleeve Gastrectomy in Adolescents and Young Adults With Obesity"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-0567","authenticated-orcid":false,"given":"Ana Paola","family":"L\u00f3pez L\u00f3pez","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , 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