{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:46:59Z","timestamp":1787021219739,"version":"build-2736575974"},"reference-count":52,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n de la Sociedad Espa\u00f1ola de Endocrinolog\u00eda y Nutrici\u00f3n"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Patients with obesity have an overactivated renin-angiotensin-aldosterone system (RAAS) that is associated with essential hypertension. However, the influence of obesity in primary aldosteronism (PA) is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We analyzed the effect of obesity on the characteristics of PA, and the association between obesity and RAAS components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted of the Spanish PA Registry (SPAIN-ALDO Registry), which included patients with PA seen at 20 tertiary centers between 2018 and 2022. Differences between patients with and without obesity were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 415 patients were included; 189 (45.5%) with obesity. Median age was 55 years (range, 47.3-65.2 years) and 240 (58.4%) were male. Compared to those without obesity, patients with obesity had higher rates of diabetes mellitus, chronic kidney disease, obstructive apnea syndrome, left ventricular hypertrophy, prior cardiovascular events, higher means of systolic blood pressure, and required more antihypertensive drugs. Patients with PA and obesity also had higher values of serum glucose, glycated hemoglobin A1c, creatinine, uric acid, and triglycerides, and lower levels of high-density lipoprotein cholesterol. Levels of blood aldosterone (PAC) and renin were similar between patients with and without obesity. Body mass index was not correlated with PAC nor renin. The rates of adrenal lesions on imaging studies, as well as the rates of unilateral disease assessed by adrenal vein sampling or I-6\u03b2-iodomethyl-19-norcholesterol scintigraphy, were similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Obesity in PA patients involves a worse cardiometabolic profile, and need for more antihypertensive drugs but similar PAC and renin levels, and rates of adrenal lesions and lateral disease than patients without obesity. However, obesity implicates a lower rate of hypertension cure after adrenalectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgad400","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T20:15:37Z","timestamp":1689020137000},"page":"e379-e388","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Obesity on Clinical Characteristics of Primary Aldosteronism Patients at Diagnosis and Postsurgical Response"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-9354","authenticated-orcid":false,"given":"Jorge Gabriel","family":"Ruiz-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Endocrinology & Nutrition Department, Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS FJD, UAM), Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz , 28040 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7803-089X","authenticated-orcid":false,"given":"Miguel","family":"Paja-Fano","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, OSI Bilbao-Basurto, Medicine Department, Basque Country University, Hospital Universitario de Basurto , 48013 Bilbao , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marga","family":"Gonz\u00e1lez Boillos","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario de Castell\u00f3n , 12004 Castell\u00f3n , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Pla Peris","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario de Castell\u00f3n , 12004 Castell\u00f3n , 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Nutrition Department, Hospital Universitario La Paz , 28046 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Vicente Delgado","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario de Toledo , 45007 Toledo , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"G\u00f3mez Hoyos","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario de Valladolid , 47003 Valladolid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario de La Princesa , 28006 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Garc\u00eda Sanz","sequence":"additional","affiliation":[{"name":"General & Digestive Surgery Department, 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Guardiola","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Infanta Sof\u00eda , 28702 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jes\u00fas","family":"Garc\u00eda Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Virgen de la Macarena , 41009 Sevilla , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina M","family":"Perdomo","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Cl\u00ednica Universidad de Navarra , 31008 Pamplona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Manj\u00f3n Migu\u00e9lez","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias , 33011 Oviedo , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Garc\u00eda Centeno","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Gregorio Mara\u00f1\u00f3n , 28007 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Percovich","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Gregorio Mara\u00f1\u00f3n , 28007 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Rebollo Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Reina Sof\u00eda , 14004 C\u00f3rdoba , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gracia Gimeno","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Royo Villanova , 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