{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:50:26Z","timestamp":1788915026110,"version":"build-2803163510"},"reference-count":32,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>For some, chronic lymphocytic thyroiditis (Hashimoto thyroiditis) is an important risk factor for differentiated thyroid cancer (DTC). Surgical cohort studies even suggested a potential role for thyroid peroxidase antibodies (TPO-Abs) on that risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Our clinical observations argued against that possibility. We designed the present study to evaluate the relationship of TPO-Abs and DTC in a large patient population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We recruited individuals who underwent thyroidectomies at 4 different clinical sites (USA: 1 clinic, 2000-2013, and Greece: 3 clinics, 2007-2021). We gathered data on TPO-Abs titers measured with commercially available chemiluminescence immunoassays, and reviewed patients\u2019 data including surgical pathology. TPO-Abs of 34 IU\/mL or greater was deemed positive (TPO+) and TPO-Abs less than 34 IU\/mL was deemed negative (TPO\u2013). Odds ratios (OR) for DTC were calculated with the Fisher exact test and P less than .05 was deemed significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We reviewed data from 8461 consecutive thyroid surgery cases. TPO-Abs titers were available for 1635 individuals: DTC n = 716 (43.8%), benign pathology n = 919 (56.2%), TPO+ n = 540 (33.0%), and TPO\u2212 n = 1095 (67.0%). DTC was found at a lower frequency in TPO+ (198\/540, 36.7%) compared to TPO\u2212 (518\/1095, 47.3%) patients, OR 0.64 (0.52-0.80; P &amp;lt; .0001). Rising TPO-Abs titers conferred protection against DTC in a linear fashion: TPO-Abs less than 10 IU\/mL: 59.3%, TPO-Abs less than 34 IU\/mL: 47.4%, TPO-Abs 34 to 100 IU\/mL: 42.6%, TPO-Abs 100 to 500 IU\/mL: 32.0%, TPO-Abs greater than 1000 IU\/mL: 19.4%; P less than .0001.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Higher TPO-Ab titers appear protective against DTC in our large multicenter cohort of patients who underwent thyroidectomies. Rising preoperative TPO-Abs titers conferred linearly increasing protection against DTC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad408","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T17:34:37Z","timestamp":1689269677000},"page":"e347-e355","source":"Crossref","is-referenced-by-count":10,"title":["Elevated Preoperative TPO Ab Titers Decrease Risk for DTC in a Linear Fashion: A Retrospective Analysis of 1635 Cases"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-0859","authenticated-orcid":false,"given":"Rodis","family":"Paparodis","sequence":"first","affiliation":[{"name":"Center for Diabetes and Endocrine Research, College of Medicine and Life Sciences (formerly Medical College of Ohio), University of Toledo , Toledo, OH 43606 , USA"},{"name":"Private Practice , Patras 26221 , 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