{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:09Z","timestamp":1792788309188,"version":"4.5.0"},"reference-count":47,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Clinical Research Fellowship"},{"DOI":"10.13039\/100005693","name":"Parent Project Muscular Dystrophy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008572","name":"University of Ottawa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008572","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014429","name":"Children's Hospital of Eastern Ontario Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Prevention of fractures is an unmet need in glucocorticoid (GC)-treated Duchenne muscular dystrophy. This study explored factors associated with incident vertebral fractures (VFs) to inform future fracture prevention efforts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>VFs were evaluated prospectively at study baseline and 12 months on lateral spine radiographs in participants aged 4 to 25 years with Duchenne muscular dystrophy. Clinical factors were analyzed for their association with the change in Spinal Deformity Index (sum of the Genant-defined VF grades from T4 to L4) between baseline and 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-eight males were evaluated (mean \u00b1 SD age at baseline 11.0 \u00b1 3.6 years; mean \u00b1 SD GC duration at baseline 4.1 \u00b1 3.1 years; 74% ambulatory). Nine of 38 participants (24%) had 17 incident VFs, of which 3\/17 VFs (18%) were moderate\/severe. Participants with 12-month incident VF had lower mean \u00b1 SD baseline lumbar spine areal bone mineral density Z-scores (\u22122.9 \u00b1 1.0 vs \u22121.9 \u00b1 1.1; P = .049) and lower total body less head areal bone mineral density Z-scores (\u22123.1 \u00b1 1.2 vs \u22121.6 \u00b1 1.7; P = .036). Multivariable linear regression showed that at least 1 VF at baseline (P &amp;lt; .001), a higher number of antecedent non-VF (P &amp;lt; .001), and greater bone age delay at baseline (P = .027) were significant predictors of an increase in the Spinal Deformity Index from baseline to 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The observation that \u2265 1 prevalent VF and\/or non-VF were the strongest predictors of incident VFs at 12 months supports the need for prevention of first fractures in this high-risk setting. Bone age delay, a marker of GC exposure, may assist in the prioritization of patients in efforts to prevent first fractures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgad435","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T16:04:44Z","timestamp":1691165084000},"page":"536-548","source":"Crossref","is-referenced-by-count":18,"title":["Risk Factors Associated with Incident Vertebral Fractures in Steroid-treated Males with Duchenne Muscular Dystrophy"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-2853","authenticated-orcid":false,"given":"Kim","family":"Phung","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology, Children's Hospital of Eastern Ontario, University of Ottawa , Ottawa, ON K1N 6N5 , Canada"},{"name":"The Ottawa Pediatric Bone Health Research Group, Children's Hospital of Eastern Ontario Research Institute , Ottawa, ON K1H 8L1 , 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