{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:11:52Z","timestamp":1777918312167,"version":"3.51.4"},"reference-count":36,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital Yunlin Branch","doi-asserted-by":"publisher","award":["NTUHYL 112-X013"],"award-info":[{"award-number":["NTUHYL 112-X013"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Atrial fibrillation (AF) has been linked to increased hyperthyroidism risk, but contributing factors are unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to investigate whether AF could predict hyperthyroidism and related risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cohort study was conducted in a tertiary medical institution and included patients aged 18 years or older with AF but without hyperthyroidism at diagnosis. The endpoint was defined as newly diagnosed hyperthyroidism during the follow-up period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study cohort included 8552 participants. Patients who developed new hyperthyroidism were younger and the proportion of females was higher. They had fewer comorbidities, including diabetes (26% vs 29%, P = .121), hypertension (51% vs 58%, P &amp;lt; .001), coronary artery disease (17% vs 25%, P &amp;lt; .001), stroke (16% vs 22%, P &amp;lt; .001), and end-stage renal disease (ESRD) (6% vs 10%, P = .001). The CHADS2 score was lower in patients with hyperthyroidism (1.74 vs 2.05, P = .031), but there was no statistically significant difference in the CHA2DS2-VASc and HAS-BLED score. Cox regression analysis identified younger age, female gender, history of congestive heart failure, hypertension, diabetes, non-ESRD status, and lower CHADS2 score but not CHA2DS2-VASc as independent predictors of incident hyperthyroidism during follow-up. We also propose a novel, simple risk stratification score (SAD HEC2 score) with excellent predictive power for incident hyperthyroidism during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results provide insight into clinical risk factors for the development of hyperthyroidism in AF patients, as identified by the novel SAD HEC2 score. AF appears to be a common precursor of hyperthyroidism.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad448","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T09:21:05Z","timestamp":1691745665000},"page":"92-99","source":"Crossref","is-referenced-by-count":7,"title":["Higher Risk of Incident Hyperthyroidism in Patients With Atrial Fibrillation"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-2486","authenticated-orcid":false,"given":"Pang-Shuo","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch , Yun-Lin 640 , Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University , Taipei 100 , Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital , Taipei 100 , 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