{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:53:01Z","timestamp":1783479181521,"version":"3.55.0"},"reference-count":56,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Health and Medical Research Council Investigator"},{"name":"National Health and Medical Research Council Postgraduate Scholarship"},{"name":"National Heart Foundation PhD Scholarship"},{"name":"Royal Australasian College of Physicians Vincent Fairfax Family Foundation Research Entry Scholarship"},{"name":"Victorian Government\u2019s Operational Infrastructure Scheme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Primary aldosteronism (PA) is the most common endocrine cause of hypertension. The final diagnostic step involves subtyping, using adrenal vein sampling (AVS), to determine if PA is unilateral or bilateral. The complete PA diagnostic process is time and resource intensive, which can impact rates of diagnosis and treatment. Previous studies have developed tools to predict bilateral PA before AVS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Evaluate the sensitivity and specificity of published tools that aim to identify bilateral subtypes of PA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Medline and Embase databases were searched to identify published models that sought to subtype PA, and algorithms to predict bilateral PA are reported. Meta-analysis and meta-regression were then performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 35 studies included, evaluating 55 unique algorithms to predict bilateral PA. The algorithms were grouped into 6 categories: those combining biochemical, radiological, and demographic characteristics (A); confirmatory testing alone or combined with biochemical, radiological, and demographic characteristics (B); biochemistry results alone (C); adrenocorticotropic hormone stimulation testing (D); anatomical imaging (E); and functional imaging (F). Across the identified algorithms, sensitivity and specificity ranged from 5% to 100% and 36% to 100%, respectively. Meta-analysis of 30 unique predictive tools from 32 studies showed that the group A algorithms had the highest specificity for predicting bilateral PA, while group F had the highest sensitivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite the variability in published predictive algorithms, they are likely important for decision-making regarding the value of AVS. Prospective validation may enable medical treatment upfront for people with a high likelihood of bilateral PA without the need for an invasive and resource-intensive test.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad451","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T20:57:39Z","timestamp":1691009859000},"page":"e837-e855","source":"Crossref","is-referenced-by-count":13,"title":["Predicting Bilateral Subtypes of Primary Aldosteronism Without Adrenal Vein Sampling: A Systematic Review and Meta-analysis"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6649-032X","authenticated-orcid":false,"given":"Elisabeth","family":"Ng","sequence":"first","affiliation":[{"name":"Centre for Endocrinology & Metabolism, Hudson Institute of Medical Research , Clayton , Australia"},{"name":"Department of Endocrinology, Monash Health , Clayton , Australia"},{"name":"Department of Molecular and Translational Science, Monash University , Clayton , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella May","family":"Gwini","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology & Metabolism, Hudson Institute of Medical Research , Clayton , Australia"},{"name":"School of Public Health and Preventive Medicine, Monash University , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Monash Health , Clayton , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Fuller","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology & Metabolism, Hudson Institute of Medical Research , Clayton , Australia"},{"name":"Department of Endocrinology, Monash Health , Clayton , Australia"},{"name":"Department of Molecular and Translational Science, Monash University , Clayton , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-4976","authenticated-orcid":false,"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology & Metabolism, Hudson Institute of Medical Research , Clayton , Australia"},{"name":"Department of Endocrinology, Monash Health , Clayton , Australia"},{"name":"Department of Molecular and Translational Science, Monash University , Clayton , Australia"},{"name":"Department of Medicine, Monash University , Clayton , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"issue":"6","key":"2024011817402628600_dgad451-B1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/jamasurg.2021.0254","article-title":"Outcomes of a specialized clinic on rates of investigation and treatment of primary aldosteronism","volume":"156","author":"Liu","year":"2021","journal-title":"JAMA Surg"},{"issue":"5","key":"2024011817402628600_dgad451-B2","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024011817402628600_dgad451-B3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s42155-021-00220-y","article-title":"Adrenal vein sampling: technique and protocol, a systematic review","volume":"4","author":"Quencer","year":"2021","journal-title":"CVIR Endovasc"},{"key":"2024011817402628600_dgad451-B4","doi-asserted-by":"crossref","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"2024011817402628600_dgad451-B5","author":"Ng"},{"issue":"8","key":"2024011817402628600_dgad451-B6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"issue":"1","key":"2024011817402628600_dgad451-B7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13690-021-00747-5","article-title":"Metadta: a stata command for meta-analysis and meta-regression of diagnostic test accuracy data\u2014a tutorial","volume":"80","author":"Nyaga","year":"2022","journal-title":"Arch Public Health"},{"issue":"9","key":"2024011817402628600_dgad451-B8","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jclinepi.2005.01.016","article-title":"The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed","volume":"58","author":"Deeks","year":"2005","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"2024011817402628600_dgad451-B9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/jhh.2016.61","article-title":"Significance of adrenal computed tomography in predicting laterality and indicating adrenal vein sampling in primary aldosteronism","volume":"31","author":"Kamemura","year":"2017","journal-title":"J Hum Hypertens"},{"issue":"6","key":"2024011817402628600_dgad451-B10","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/cen.12998","article-title":"Subtype prediction in primary aldosteronism: measurement of circadian variation of adrenocortical hormones and 24-h urinary aldosterone","volume":"84","author":"Kobayashi","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"2024011817402628600_dgad451-B11","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1097\/HJH.0000000000001855","article-title":"Development and validation of subtype prediction scores for the workup of primary aldosteronism","volume":"36","author":"Kobayashi","year":"2018","journal-title":"J Hypertens"},{"key":"2024011817402628600_dgad451-B12","doi-asserted-by":"crossref","first-page":"645395","DOI":"10.3389\/fendo.2021.645395","article-title":"Should adrenal venous sampling be performed in PA patients without apparent adrenal tumors?","volume":"12","author":"Okamoto","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"2024011817402628600_dgad451-B13","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1210\/jc.2017-01774","article-title":"Significance of computed tomography and serum potassium in predicting subtype diagnosis of primary aldosteronism","volume":"103","author":"Umakoshi","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2024011817402628600_dgad451-B14","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/cen.13962","article-title":"A novel clinical nomogram to predict bilateral hyperaldosteronism in Chinese patients with primary aldosteronism","volume":"90","author":"Xiao","year":"2019","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2024011817402628600_dgad451-B15","doi-asserted-by":"crossref","first-page":"e210532","DOI":"10.1530\/EC-21-0532","article-title":"Validation of three novel clinical prediction tools for primary aldosteronism subtyping","volume":"11","author":"Kocjan","year":"2022","journal-title":"Endocr Connect"},{"issue":"7","key":"2024011817402628600_dgad451-B16","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1097\/HJH.0000000000002348","article-title":"Aldosterone-potassium ratio predicts primary aldosteronism subtype","volume":"38","author":"Puar","year":"2020","journal-title":"J Hypertens"},{"issue":"4","key":"2024011817402628600_dgad451-B17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/ajh\/hpab195","article-title":"External validation of clinical prediction models in unilateral primary aldosteronism","volume":"35","author":"Sam","year":"2022","journal-title":"Am J Hypertens"},{"key":"2024011817402628600_dgad451-B18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3389\/fendo.2019.00739","article-title":"Circulating miRNA expression profiling in primary aldosteronism","volume":"10","author":"Decmann","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"2024011817402628600_dgad451-B19","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1210\/jc.2011-2384","article-title":"18-hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypes","volume":"97","author":"Mulatero","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2024011817402628600_dgad451-B20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jsbmb.2019.01.008","article-title":"Classification of microadenomas in patients with primary aldosteronism by steroid profiling","volume":"189","author":"Yang","year":"2019","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"2024011817402628600_dgad451-B21","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1161\/HYPERTENSIONAHA.114.04453","article-title":"Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism","volume":"65","author":"Satoh","year":"2015","journal-title":"Hypertension"},{"issue":"3","key":"2024011817402628600_dgad451-B22","doi-asserted-by":"crossref","first-page":"e319","DOI":"10.1210\/clinem\/dgz092","article-title":"Aldosterone reduction rate after saline infusion test may be a novel prediction in patients with primary aldosteronism","volume":"105","author":"Nagano","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024011817402628600_dgad451-B23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/cen.13757","article-title":"Saline suppression test parameters may predict bilateral subtypes of primary aldosteronism","volume":"89","author":"Hashimura","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2024011817402628600_dgad451-B24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/cen.13278","article-title":"Scoring system for the diagnosis of bilateral primary aldosteronism in the outpatient setting before adrenal venous sampling","volume":"86","author":"Kobayashi","year":"2017","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2024011817402628600_dgad451-B25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1507\/endocrj.EJ20-0329","article-title":"Prediction of unilateral hyperaldosteronism on adrenal vein sampling using captopril challenge test in patients with primary aldosteronism","volume":"68","author":"Wada","year":"2021","journal-title":"Endocr J"},{"issue":"2","key":"2024011817402628600_dgad451-B26","doi-asserted-by":"crossref","first-page":"e866","DOI":"10.1210\/clinem\/dgaa812","article-title":"Significance of discordant results between confirmatory tests in diagnosis of primary aldosteronism","volume":"106","author":"Fukumoto","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2024011817402628600_dgad451-B27","doi-asserted-by":"crossref","first-page":"e3706","DOI":"10.1210\/clinem\/dgaa379","article-title":"Development and validation of prediction dodels for subtype diagnosis of patients with primary aldosteronism","volume":"105","author":"Burrello","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024011817402628600_dgad451-B28","doi-asserted-by":"crossref","first-page":"587","DOI":"10.4158\/EP15982.OR","article-title":"A new clinical prediction criterion accurately determines a subset of patients with bilateral primary aldosteronism before adrenal venous sampling","volume":"22","author":"Kocjan","year":"2016","journal-title":"Endocr Pract"},{"issue":"7","key":"2024011817402628600_dgad451-B29","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.3390\/diagnostics12071718","article-title":"Adrenal venous sampling could be omitted before surgery in patients with Conn's adenoma confirmed by computed tomography and higher normal aldosterone concentration after saline infusion test","volume":"12","author":"Holaj","year":"2022","journal-title":"Diagnostics (Basel)"},{"issue":"4","key":"2024011817402628600_dgad451-B30","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s40292-022-00523-8","article-title":"Machine learning approach to predict subtypes of primary aldosteronism is helpful to estimate indication of adrenal vein sampling","volume":"29","author":"Tamaru","year":"2022","journal-title":"High Blood Press Cardiovasc Prev"},{"issue":"5","key":"2024011817402628600_dgad451-B31","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1210\/jc.2014-3551","article-title":"Diagnostic value of ACTH stimulation test in determining the subtypes of primary aldosteronism","volume":"100","author":"Jiang","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024011817402628600_dgad451-B32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1507\/endocrj.EJ16-0297","article-title":"ACTH stimulation test and computed tomography are useful for differentiating the subtype of primary aldosteronism","volume":"64","author":"Moriya","year":"2017","journal-title":"Endocr J"},{"issue":"3","key":"2024011817402628600_dgad451-B33","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1148\/radiology.184.3.1509049","article-title":"Distinction between hyperaldosteronism due to bilateral hyperplasia and unilateral aldosteronoma: reliability of CT","volume":"184","author":"Doppman","year":"1992","journal-title":"Radiology"},{"issue":"5","key":"2024011817402628600_dgad451-B34","doi-asserted-by":"crossref","first-page":"e2087","DOI":"10.1210\/clinem\/dgab047","article-title":"Adrenal venous sampling in young patients with primary aldosteronism. Extravagance or irreplaceable?","volume":"106","author":"Gkaniatsa","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024011817402628600_dgad451-B35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3803\/EnM.2020.901","article-title":"Diagnostic accuracy of computed tomography in predicting primary aldosteronism subtype according to age","volume":"36","author":"Lee","year":"2021","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"2","key":"2024011817402628600_dgad451-B36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/HJH.0000000000002271","article-title":"Left versus right adrenal volume ratio as a screening index before adrenal venous sampling to identify unilateral primary aldosteronism patients","volume":"38","author":"Li","year":"2020","journal-title":"J Hypertens"},{"issue":"3","key":"2024011817402628600_dgad451-B37","first-page":"1066","article-title":"Comparison of adrenal vein sampling and computed tomography in the differentiation of primary aldosteronism","volume":"86","author":"Magill","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024011817402628600_dgad451-B38","first-page":"414","article-title":"Diagnostic performance of multidetector computed tomography in distinguishing unilateral from bilateral abnormalities in primary hyperaldosteronism: comparison of multidetector computed tomography with adrenal vein sampling","volume":"39","author":"Raman","year":"2015","journal-title":"J Comput Assist Tomogr"},{"issue":"2","key":"2024011817402628600_dgad451-B39","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1148\/radiology.214.2.r00fe09527","article-title":"Primary hyperaldosteronism (Conn syndrome): MR imaging findings","volume":"214","author":"Sohaib","year":"2000","journal-title":"Radiology"},{"issue":"4","key":"2024011817402628600_dgad451-B40","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1210\/jc.2007-2055","article-title":"Roles of clinical criteria, computed tomography scan, and adrenal vein sampling in differential diagnosis of primary aldosteronism subtypes","volume":"93","author":"Mulatero","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024011817402628600_dgad451-B41","first-page":"43","article-title":"Limited significance of asymmetric adrenal visualization on dexamethasone-suppression scintigraphy","volume":"26","author":"Gross","year":"1985","journal-title":"J Nucl Med"},{"issue":"6","key":"2024011817402628600_dgad451-B42","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1097\/HJH.0000000000003132","article-title":"11C-metomidate PET-CT versus adrenal vein sampling to subtype primary aldosteronism: a prospective clinical trial","volume":"40","author":"Puar","year":"2022","journal-title":"J Hypertens"},{"issue":"6","key":"2024011817402628600_dgad451-B43","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1530\/EJE-20-0532","article-title":"Functional imaging with 11C-metomidate PET for subtype diagnosis in primary aldosteronism","volume":"183","author":"Soinio","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"2024011817402628600_dgad451-B44","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1210\/jc.2012-1917","article-title":"A clinical prediction score to diagnose unilateral primary aldosteronism","volume":"97","author":"K\u00fcpers","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2024011817402628600_dgad451-B45","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/jhh.2014.20","article-title":"A subtype prediction score for primary aldosteronism","volume":"28","author":"Nanba","year":"2014","journal-title":"J Hum Hypertens"},{"issue":"12","key":"2024011817402628600_dgad451-B46","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1210\/jcem.85.12.7086","article-title":"Predictive value of preoperative tests in discriminating bilateral adrenal hyperplasia from an aldosterone-producing adrenal adenoma","volume":"85","author":"Phillips","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024011817402628600_dgad451-B47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s40618-019-01114-6","article-title":"A clinical prediction score using age at diagnosis and saline infusion test parameters can predict aldosterone-producing adenoma from idiopathic adrenal hyperplasia","volume":"43","author":"Leung","year":"2020","journal-title":"J Endocrinol Invest"},{"issue":"8","key":"2024011817402628600_dgad451-B48","doi-asserted-by":"crossref","first-page":"830","DOI":"10.4158\/EP-2019-0009","article-title":"The potential clinical application of a lower bilateral adrenal limb width ratio (L\/Rw) in patients with bilateral primary hyperaldosteronism","volume":"25","author":"Li","year":"2019","journal-title":"Endocr Pract"},{"key":"2024011817402628600_dgad451-B49","doi-asserted-by":"crossref","first-page":"645488","DOI":"10.3389\/fendo.2021.645488","article-title":"Cortisol co-secretion and clinical usefulness of ACTH stimulation test in primary aldosteronism: a systematic review and biases in epidemiological studies","volume":"12","author":"Inoue","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"11","key":"2024011817402628600_dgad451-B50","doi-asserted-by":"crossref","first-page":"e4340","DOI":"10.1210\/clinem\/dgab482","article-title":"Identification of surgically curable primary aldosteronism by imaging in a large, multiethnic international study","volume":"106","author":"Rossi","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024011817402628600_dgad451-B51","doi-asserted-by":"crossref","first-page":"329","DOI":"10.7326\/0003-4819-151-5-200909010-00007","article-title":"Systematic review: diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism","volume":"151","author":"Kempers","year":"2009","journal-title":"Ann Intern Med"},{"issue":"5","key":"2024011817402628600_dgad451-B52","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0895-7061(01)02312-3","article-title":"Unilateral adrenal hyperplasia causing primary aldosteronism: limitations of I-131 norcholesterol scanning","volume":"15","author":"Mansoor","year":"2002","journal-title":"Am J Hypertens"},{"issue":"4","key":"2024011817402628600_dgad451-B53","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/ijms18040848","article-title":"Subtype diagnosis of primary aldosteronism: is adrenal vein sampling always necessary?","volume":"18","author":"Buffolo","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2024011817402628600_dgad451-B54","doi-asserted-by":"crossref","first-page":"e2027","DOI":"10.1210\/clinem\/dgab924","article-title":"The saline infusion test for primary aldosteronism: implications of immunoassay inaccuracy","volume":"107","author":"Eisenhofer","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2024011817402628600_dgad451-B55","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3390\/jcm9051447","article-title":"Adrenal vein sampling to distinguish between unilateral and bilateral primary hyperaldosteronism: to ACTH stimulate or not?","volume":"9","author":"Sung","year":"2020","journal-title":"J Clin Med"},{"issue":"4","key":"2024011817402628600_dgad451-B56","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/cen.14220","article-title":"Utility of adrenocorticotropic hormone in adrenal vein sampling despite the occurrence of discordant lateralization","volume":"93","author":"Chee","year":"2020","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgad451\/51076620\/dgad451.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/109\/2\/e837\/55521930\/dgad451.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/109\/2\/e837\/55521930\/dgad451.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T17:41:13Z","timestamp":1705599673000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/109\/2\/e837\/7235921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,8,2]]},"published-print":{"date-parts":[[2024,1,18]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgad451","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2023,8,2]]}}}