{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:35:03Z","timestamp":1790753703295,"version":"4.1.0"},"reference-count":61,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["56843615)."],"award-info":[{"award-number":["56843615)."]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Skeletal fragility is observed in 30% to 60% of acromegaly patients, representing an emerging complication of the disease that increases disability. Despite several studies having investigated the clinical and hormonal prognostic factors for the occurrence of vertebral fractures (VFs) in acromegaly, very few data are available on their prevention\/treatment including the effect of vitamin D (VD) supplementation, which has been reported to have a fracture-protective effect in several studies in patients with osteoporosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to investigate the role of cholecalciferol (D3) supplementation in the prevention of incident VFs (i-VFs) in acromegaly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A longitudinal, retrospective and multicenter study was performed on 61 acromegaly patients treated and untreated with D3 supplementation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-six patients were treated with D3 supplementation according to clinical guidelines. The median D3 weekly dosage was 8500 IU (interquartile range [IQR]: 3900). The median duration of D3 supplementation was 94 months (IQR: 38). At last follow-up, i-VFs were diagnosed in 14 patients (23%). I-VFs were less prevalent in patients on D3 supplementation (14.3% of cases) compared to patients not treated with D3 (85.7%; P = .02). The final level of serum V25OH-D was significantly lower in patients who developed i-VFs (28.6 ng\/mL, IQR: 4.1) compared to patients who did not develop i-VFs (34.2 ng\/mL, IQR: 9.6; P = .05). The logistic regression confirmed the protective role of D3 supplementation on the occurrence of i-VFs (odds ratio: 0.16; 95% CI, 0.03-0.79; P = .01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>It is likely that D3 supplementation could lead to a reduction in i-VFs in acromegaly.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad493","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T11:33:42Z","timestamp":1692704022000},"page":"e58-e68","source":"Crossref","is-referenced-by-count":23,"title":["Cholecalciferol Use Is Associated With a Decreased Risk of Incident Morphometric Vertebral Fractures in Acromegaly"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-2392","authenticated-orcid":false,"given":"Sabrina","family":"Chiloiro","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Pituitary Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS , Rome 00168 , Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-5598","authenticated-orcid":false,"given":"Stefano","family":"Frara","sequence":"additional","affiliation":[{"name":"Institute of Endocrine and Metabolic Sciences, Universit\u00e0 Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele , Milan 20132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3280-8592","authenticated-orcid":false,"given":"Irene","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Endocrinology, Geriatrics & Internal Medicine, University of Ferrara , Ferrara 44121 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4896-5499","authenticated-orcid":false,"given":"Antonio","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Pituitary Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS , Rome 00168 , Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5756-2045","authenticated-orcid":false,"given":"Antonella","family":"Giampietro","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Pituitary Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS , Rome 00168 , Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Medici","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Endocrinology, Geriatrics & Internal Medicine, University of Ferrara , Ferrara 44121 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Allora","sequence":"additional","affiliation":[{"name":"Institute of Endocrine and Metabolic Sciences, Universit\u00e0 Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele , Milan 20132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"di Filippo","sequence":"additional","affiliation":[{"name":"Institute of Endocrine and Metabolic Sciences, Universit\u00e0 Vita-Salute San Raffaele, IRCCS Ospedale San Raffaele , Milan 20132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Endocrinology, Geriatrics & Internal Medicine, University of Ferrara , Ferrara 44121 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-6865","authenticated-orcid":false,"given":"Alfredo","family":"Pontecorvi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Pituitary Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS , Rome 00168 , Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore , Rome 00168 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-7796","authenticated-orcid":false,"given":"Maria Chiara","family":"Zatelli","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Endocrinology, Geriatrics & Internal Medicine, University of Ferrara , Ferrara 44121 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9916-0669","authenticated-orcid":false,"given":"Laura","family":"De Marinis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Pituitary Unit, Fondazione Policlinico Universitario A. 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