{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:52:11Z","timestamp":1790707931195,"version":"4.1.0"},"reference-count":46,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Male hypogonadism is associated with visceral obesity and the metabolic syndrome: factors important for the development of nonalcoholic fatty liver disease (NAFLD). The Testosterone Trials (The T Trials) showed testosterone (T) treatment compared with placebo in older hypogonadal men was associated with decreases in cholesterol and insulin levels suggesting that T treatment may improve NAFLD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Compare effects of T vs placebo treatment on NAFLD scores and liver scans in elderly hypogonadal men.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Secondary data analyses from 479 older hypogonadal men with total T &amp;lt; 275 ng\/dL from The T Trials were performed. Three clinical liver fat scores\u2014lipid accumulation product index, hepatic steatosis index, nonalcoholic fatty liver disease-metabolic syndrome score\u2014and liver computed tomography (CT) Hounsfield units and liver to spleen ratio were evaluated at baseline and 12 months after treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were no statistically significant differences of change in lipid accumulation product index (P = .98), hepatic steatosis index (P = .67), and nonalcoholic fatty liver disease-metabolic syndrome (P = .52) in 246 men treated with T compared with 233 treated with placebo for 12 months. Liver CT showed no statistically significant difference of change in Hounsfield units (P = .24; n = 71 for T, n = 69 for placebo) and liver to spleen ratio (P = .74; n = 55 for T, n = 62 for placebo) between the 2 groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study did not show improvement of NAFLD in older hypogonadal men after 12 months of T vs placebo treatment, as assessed by 3 clinical scores and liver CT for hepatic steatosis. Future studies with longer treatment duration and additional NAFLD diagnostic modalities as primary outcome are warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad511","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:27:35Z","timestamp":1693582055000},"page":"e757-e764","source":"Crossref","is-referenced-by-count":14,"title":["The Effect of Testosterone Replacement Therapy on Nonalcoholic Fatty Liver Disease in Older Hypogonadal Men"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-0403","authenticated-orcid":false,"given":"Hae Seung","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, The Lundquist Institute and Harbor-UCLA Medical Center , Torrance, CA 90502 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hun","family":"Han","sequence":"additional","affiliation":[{"name":"Division of 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