{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:09:33Z","timestamp":1780704573420,"version":"3.54.1"},"reference-count":106,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Liaoning Science and Technology Plan Project","award":["2021JH2\/10300118"],"award-info":[{"award-number":["2021JH2\/10300118"]}]},{"name":"The 345 Talent Project Program of China Medical University Shengjing Hospital","award":["2022-50A"],"award-info":[{"award-number":["2022-50A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cholesterol gallstone disease (CGD) is one of the most common digestive diseases, and it is closely associated with hepatic cholesterol metabolism. Cholesterol gallstones may be caused by abnormal hepatic cholesterol metabolism, such as excessive cholesterol biosynthesis within the liver, interfering with the uptake or export of cholesterol in the liver, and abnormal hepatic cholesterol esterification. In this review, we begin with a brief overview of the clinical diagnosis and treatment of gallstone disease (GSD). Then, we briefly describe the major processes of hepatic cholesterol metabolism and summarize the key molecular expression changes of hepatic cholesterol metabolism in patients with gallstones. We review and analyze the recent advances in elucidating the relationships between these key molecules and CGD, and some targets significantly impacting on CGD via hepatic cholesterol metabolism are also listed. We also provide a significant discussion on the relationship between CGD and nonalcoholic fatty liver disease (NAFLD). Finally, the new discoveries of some therapeutic strategies associated with hepatic cholesterol metabolism to prevent and treat CGD are summarized.<\/jats:p>","DOI":"10.1210\/clinem\/dgad528","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T17:29:15Z","timestamp":1693762155000},"page":"912-923","source":"Crossref","is-referenced-by-count":27,"title":["Resistance to Cholesterol Gallstone Disease: Hepatic Cholesterol Metabolism"],"prefix":"10.1210","volume":"109","author":[{"given":"Chenghao","family":"Zhang","sequence":"first","affiliation":[{"name":"Biliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University , Shenyang, Liaoning 110004 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlin","family":"Dai","sequence":"additional","affiliation":[{"name":"Innovation Institute of China Medical University , Shenyang 110122 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Yang","sequence":"additional","affiliation":[{"name":"Biliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University , Shenyang, Liaoning 110004 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuodong","family":"Wu","sequence":"additional","affiliation":[{"name":"Biliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University , Shenyang, Liaoning 110004 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8048-3289","authenticated-orcid":false,"given":"Jing","family":"Kong","sequence":"additional","affiliation":[{"name":"Biliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University , Shenyang, Liaoning 110004 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"issue":"1","key":"2024031503435859400_dgad528-B1","doi-asserted-by":"crossref","first-page":"16024","DOI":"10.1038\/nrdp.2016.24","article-title":"Gallstones","volume":"2","author":"Lammert","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"9531","key":"2024031503435859400_dgad528-B2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(06)69044-2","article-title":"Cholesterol gallstone disease","volume":"368","author":"Portincasa","year":"2006","journal-title":"Lancet"},{"issue":"2","key":"2024031503435859400_dgad528-B3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.gtc.2010.02.007","article-title":"Lith genes and genetic analysis of cholesterol gallstone formation","volume":"39","author":"Wang","year":"2010","journal-title":"Gastroenterol Clin North 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