{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:44:48Z","timestamp":1792896288433,"version":"4.5.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"2","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ30979"],"award-info":[{"award-number":["2022JJ30979"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010031","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2022M713536"],"award-info":[{"award-number":["2022M713536"]}],"id":[{"id":"10.13039\/501100010031","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Intraoperative hemodynamic instability (HDI) can lead to cardiovascular and cerebrovascular complications during surgery for pheochromocytoma\/paraganglioma (PPGL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to assess the risk of intraoperative HDI in patients with PPGL to improve surgical outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 199 consecutive patients with PPGL confirmed by surgical pathology were retrospectively included in this study. This cohort was separated into 2 groups according to intraoperative systolic blood pressure, the HDI group (n = 101) and the hemodynamic stability (HDS) group (n = 98). It was also divided into 2 subcohorts for predictive modeling: the training cohort (n = 140) and the validation cohort (n = 59). Prediction models were developed with both the ensemble machine learning method (EL model) and the multivariate logistic regression model using body composition parameters on computed tomography, tumor radiomics, and clinical data. The efficiency of the models was evaluated with discrimination, calibration, and decision curves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The EL model showed good discrimination between the HDI group and HDS group, with an area under the curve of (AUC) of 96.2% (95% CI, 93.5%-99.0%) in the training cohort, and an AUC of 93.7% (95% CI, 88.0%-99.4%) in the validation cohort. The AUC values from the EL model were significantly higher than the logistic regression model, which had an AUC of 74.4% (95% CI, 66.1%-82.6%) in the training cohort and an AUC of 74.2% (95% CI, 61.1%-87.3%) in the validation cohort. Favorable calibration performance and clinical applicability of the EL model were observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The EL model combining preoperative computed tomography-based body composition, tumor radiomics, and clinical data could potentially help predict intraoperative HDI in patients with PPGL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad543","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T22:17:29Z","timestamp":1694729849000},"page":"351-360","source":"Crossref","is-referenced-by-count":17,"title":["Ensemble Machine Learning Model Incorporating Radiomics and Body Composition for Predicting Intraoperative HDI in PPGL"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8300-4573","authenticated-orcid":false,"given":"Yan","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Radiology, Xiangya Hospital, Central South University , Changsha 410008, Hunan, People's Republic of China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital , Changsha 410008, Hunan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xiangya Hospital, Central South University , Changsha 410008, Hunan, People's Republic of China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital , Changsha 410008, Hunan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-1981","authenticated-orcid":false,"given":"Xiaoping","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xiangya Hospital, Central South University , Changsha 410008, Hunan, People's Republic of China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital , Changsha 410008, Hunan, People's Republic of China"},{"name":"National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Central South University , Changsha 410008, Hunan, People's Republic of China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University , Changsha 410008, Hunan, People's Republic of China"},{"name":"Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University , Changsha 410008, Hunan, People's Republic of China"},{"name":"Department of Dermatology, Xiangya Hospital, Central South University , Changsha 410008, Hunan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xiangya Hospital, Central South University , Changsha 410008, Hunan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xiangya Hospital, Central South University , Changsha 410008, Hunan, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaide","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology, Xiangya Hospital, Central South University , Changsha 410008, Hunan, People's Republic of 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