{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:52:58Z","timestamp":1787496778524,"version":"build-2736575974"},"reference-count":45,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-A-064"],"award-info":[{"award-number":["2022-PUMCH-A-064"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-016"],"award-info":[{"award-number":["2022-PUMCH-B-016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the cerebrospinal fluid (CSF) metabolomic pattern of pituitary stalk lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CSF was collected from patients with different pituitary stalk lesions treated at Peking Union Medical College Hospital: germ cell tumor (GCT, n = 27); hypophysitis (n = 10); and Langerhans cell histiocytosis (LCH) or Erdheim-Chester disease (ECD) (LCH + ECD, n = 10). The CSF metabolome profiles were characterized by liquid chromatography\u2013mass spectrometry (LC-MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 44 metabolites that significantly differed between patients with GCT and those with hypophysitis (P &amp;lt; .05). Between patients with GCT with CSF level of beta subunit of human chorionic gonadotrophin (\u03b2-hCG) &amp;lt; 5\u2005mIU\/mL and those with hypophysitis, there were 15 differential metabolites (P &amp;lt; .05, fold change &amp;gt; 1.5 or &amp;lt; 1\/1.5). All of the metabolites had an area under the curve (AUC) above 0.7. There were 9 metabolites that significantly differed between patients with GCT and those with LCH + ECD (P &amp;lt; .05) and 7 metabolites had significant differences between GCT (CSF \u03b2-hCG &amp;lt; 5\u2005mIU\/mL) and LCH + ECD (P &amp;lt; .05, fold change &amp;gt; 1.5 or &amp;lt; 1\/1.5). We found 6 metabolites that were significantly different between patients with hypophysitis and those with LCH + ECD (P &amp;lt; .05) and 5 of these had fold change more than 1.5 or less than 1\/1.5. Three metabolites, 5-deoxydiplosporin, cloversaponin I, and phytosphingosine, showed excellent capabilities to differentiate the 3 disease categories. Furthermore, we identified 67 metabolites associated with clinical test results (\u03c1 &amp;gt; 0.2, P &amp;lt; .05) and 29 metabolites showed strong correlation (\u03c1 &amp;gt; 0.4, P &amp;lt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study is the first to systematically investigate the metabolomics of CSF in different pituitary stalk lesions. CSF metabolomics is a useful strategy for biomarker discovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgad559","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:26:54Z","timestamp":1695860814000},"page":"802-814","source":"Crossref","is-referenced-by-count":9,"title":["Cerebrospinal Fluid Metabolomic Pattern of Different Pituitary Stalk Lesions"],"prefix":"10.1210","volume":"109","author":[{"given":"Linjie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology of National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing 100730 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology of National Health 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