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The brain is highly sensitive to these hormones, but the consequence of having AAD for brain health has not been widely addressed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study compared resting-state functional connectivity (rs-fc) of the brain between individuals with AAD and healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-seven patients with AAD (33 female) and 69 healthy controls (39 female), aged 19 to 43 years were scanned with 3-T magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Independent component and subsequent dual regression analyses revealed that individuals with AAD had stronger rs-fc compared to controls in 3 networks: the bilateral orbitofrontal cortex (OFC), the left medial visual and left posterior default mode network. A higher GC replacement dose was associated with stronger rs-fc in a small part of the left OFC in patients. We did not find any clear associations between rs-fc and executive functions or mental fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that having AAD affects the baseline functional organization of the brain and that current treatment strategies of AAD may be one risk factor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgad592","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T17:53:47Z","timestamp":1697046827000},"page":"701-710","source":"Crossref","is-referenced-by-count":5,"title":["Increased Resting-State Functional Connectivity in Patients With Autoimmune Addison Disease"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-3058","authenticated-orcid":false,"given":"Annelies","family":"van\u2019t 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