{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:13:19Z","timestamp":1793398399840,"version":"4.5.0"},"reference-count":45,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T00:00:00Z","timestamp":1696636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"ERDF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Little is known about whether parity is associated with elevated early-pregnancy insulin resistance (IR), or whether overweight\/obesity contributes to increasing the possible effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We determined the associations between parity and glucose metabolism parameters in the first trimester of pregnancy in a Mediterranean pregnant population, and whether these associations are affected by overweight\/obesity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cross-sectional study was conducted of 264 healthy pregnant women from the ECLIPSES study who were recruited at 12 weeks of gestation. At baseline, details on socioeconomic status, obstetric history (including parity, ie, number of births), lifestyle factors, anthropometry, and blood samples were collected. Fasting serum glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) index were assessed in the first trimester. Elevated IR was defined as the upper HOMA-IR tertile (\u22651.58). Multivariable linear regression and Cox regression model with constant time were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Parity ranged from 0 to 4. After multivariable adjustment, the insulin levels (\u03b2 [% change]: 20.92; 95% CI, 4.08-37.71) and HOMA-IR index (\u03b2 [% change]: 19.72; 95% CI, 2.43-40.49) were positively associated with parity. Additionally, multiparous women, as compared to nulliparous, were more likely to have higher HOMA-IR levels (primiparous [1 birth], \u03b2 [% change[: 16.88; 95% CI, \u22121.00 to 37.99; multiparous [\u22652 births), \u03b2 [% change]: 32.18; 95% CI, 3.56-68.71), and an increased relative risk (RR) of an elevated IR (primiparous [1 birth], RR: 1.55; 95% CI, 1.03-2.36; multiparous (\u22652 births), RR: 1.72; 95% CI, 1.05-2.83). The combination of multiparity and overweight\/obesity conferred a 3.04-fold increase in the RR of elevated IR, which increased proportionally to the number of parities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study demonstrates that parity may have a negative effect on early-pregnancy IR and that maternal overweight\/obesity appears to further aggravate this relationship.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad594","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T12:12:58Z","timestamp":1696594378000},"page":"730-739","source":"Crossref","is-referenced-by-count":7,"title":["Association of Parity With Insulin Resistance Early in Pregnant Women: ECLIPSES Study"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-7610","authenticated-orcid":false,"given":"Ehsan","family":"Motevalizadeh","sequence":"first","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili (URV) , 43201 Tarragona , Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) , 43005 Tarragona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-5629","authenticated-orcid":false,"given":"Andr\u00e9s","family":"D\u00edaz-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili (URV) , 43201 Tarragona , Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) , 43005 Tarragona , Spain"},{"name":"Consorcio CIBER, M.P. Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERObn), Institute of Health Carlos III , 28029 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0359-3588","authenticated-orcid":false,"given":"Francisco","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) , 43005 Tarragona , Spain"},{"name":"Institut d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS) , 08007 Barcelona , Spain"},{"name":"Collaborative Group on Lifestyles, Nutrition, And Tobacco (CENIT), Institut d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS) , 43202 Reus , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0278-1149","authenticated-orcid":false,"given":"Josep","family":"Basora","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) , 43005 Tarragona , Spain"},{"name":"Institut d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS) , 08007 Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1758-0975","authenticated-orcid":false,"given":"Victoria","family":"Arija","sequence":"additional","affiliation":[{"name":"Nutrition and Mental Health Research Group (NUTRISAM), Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili (URV) , 43201 Tarragona , Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV) , 43005 Tarragona , Spain"},{"name":"Institut d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS) , 08007 Barcelona , Spain"},{"name":"Collaborative Group on Lifestyles, Nutrition, And Tobacco (CENIT), Institut d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria IDIAP Jordi Gol, Institut Catal\u00e0 de la Salut (ICS) , 43202 Reus , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,10,7]]},"reference":[{"key":"2024022001121666000_dgad594-B1","doi-asserted-by":"crossref","first-page":"140851","DOI":"10.1155\/2014\/140851","article-title":"Estimating rate of insulin resistance in patients with preeclampsia using HOMA-IR index and comparison with nonpreeclampsia pregnant women","volume":"2014","author":"Abhari","year":"2014","journal-title":"Biomed Res 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