{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:16:34Z","timestamp":1780917394652,"version":"3.54.1"},"reference-count":56,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:00:00Z","timestamp":1697846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["R01HD094150"],"award-info":[{"award-number":["R01HD094150"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de recherche du Qu\u00e9bec Sant\u00e9","doi-asserted-by":"publisher","award":["#20697"],"award-info":[{"award-number":["#20697"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"publisher","award":["#MOP 115071"],"award-info":[{"award-number":["#MOP 115071"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institute of Health Research","doi-asserted-by":"publisher","award":["#PJT-152989"],"award-info":[{"award-number":["#PJT-152989"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008985","name":"Diab\u00e8te Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008985","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["K24 HL157960"],"award-info":[{"award-number":["K24 HL157960"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["(#1-15-ACE-26"],"award-info":[{"award-number":["(#1-15-ACE-26"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Elevated body mass index (BMI) in pregnancy is associated with adverse maternal and fetal outcomes. The placental transcriptome may elucidate molecular mechanisms underlying these associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the association of first-trimester maternal BMI with the placental transcriptome in the Gen3G prospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled participants at 5 to 16 weeks of gestation and measured height and weight. We collected placenta samples at delivery. We performed whole-genome RNA sequencing using Illumina HiSeq 4000 and aligned RNA sequences based on the GTEx v8 pipeline. We conducted differential gene expression analysis of over 15 000 genes from 450 placental samples and reported the change in normalized gene expression per 1-unit increase in log2 BMI (kg\/m2) as a continuous variable using Limma Voom. We adjusted models for maternal age, fetal sex, gestational age at delivery, gravidity, and surrogate variables accounting for technical variability. We compared participants with BMI of 18.5 to 24.9\u2005mg\/kg2 (N = 257) vs those with obesity (BMI \u226530\u2005kg\/m2, N = 82) in secondary analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants\u2019 mean \u00b1 SD age was 28.2 \u00b1 4.4 years and BMI was 25.4 \u00b1 5.5\u2005kg\/m2 in early pregnancy. Higher maternal BMI was associated with lower placental expression of EPYC (slope = \u22121.94, false discovery rate [FDR]-adjusted P = 7.3 \u00d7 10\u22126 for continuous BMI; log2 fold change = \u22121.35, FDR-adjusted P = 3.4 \u00d7 10\u22123 for BMI \u226530 vs BMI 18.5-24.9\u2005kg\/m2) and with higher placental expression of IGFBP6, CHRDL1, and CXCL13 after adjustment for covariates and accounting for multiple testing (FDR &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our genome-wide transcriptomic study revealed novel genes potentially implicated in placental biologic response to higher maternal BMI in early pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgad619","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T21:43:16Z","timestamp":1697924596000},"page":"e1159-e1166","source":"Crossref","is-referenced-by-count":6,"title":["Higher Maternal Body Mass Index Is Associated With Lower Placental Expression of<i>EPYC:<\/i>A Genome-Wide Transcriptomic Study"],"prefix":"10.1210","volume":"109","author":[{"given":"Joanne E","family":"Sordillo","sequence":"first","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute , Boston, MA 02215 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"White","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie, Universit\u00e9 de Sherbrooke , Sherbrooke, QC J1K 2R1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Majid","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute , Boston, MA 02215 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Aguet","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics, Broad Institute , Cambridge, MA 02142 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin G","family":"Ardlie","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics, Broad Institute , Cambridge, MA 02142 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Ananth","family":"Karumanchi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C","family":"Florez","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics, Broad Institute , Cambridge, MA 02142 , USA"},{"name":"Diabetes Unit, Massachusetts General Hospital, and Harvard Medical School , Boston, MA 02114 , USA"},{"name":"Center for Genomic Medicine, Massachusetts General Hospital , Boston, MA 02114 , USA"},{"name":"Department of Medicine, Harvard Medical School , Boston, MA 02215 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7060-7778","authenticated-orcid":false,"given":"Camille E","family":"Powe","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics, Broad Institute , Cambridge, MA 02142 , USA"},{"name":"Department of Medicine, Harvard Medical School , Boston, MA 02215 , USA"},{"name":"Department of Obstetrics and Gynecology, Massachusetts General Hospital , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-5949","authenticated-orcid":false,"given":"Andrea G","family":"Edlow","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Massachusetts General Hospital , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Functional Genomics, Universit\u00e9 de Sherbrooke , Sherbrooke, QC J1H 5N4 , Canada"},{"name":"Department of Medical Biology, CIUSSS of Saguenay-Lac-Saint-Jean , Saguenay, QC G7H 7K9 , Canada"},{"name":"Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS) , Sherbrooke, QC J1H 5N3 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Etienne","family":"Jacques","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie, Universit\u00e9 de Sherbrooke , Sherbrooke, QC J1K 2R1 , Canada"},{"name":"Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS) , Sherbrooke, QC J1H 5N3 , 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