{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:54:21Z","timestamp":1782845661408,"version":"3.54.5"},"reference-count":15,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thymomas are benign thymic epithelial neoplasms, rarely found outside the anterior mediastinum. Although hyperthyroid states have been associated with thymic hyperplasia, only 3 thymoma cases have been previously reported in patients with Graves disease (GD), all within the anterior mediastinum. Here, we report a case of ectopic cervical thymoma in a 22-year-old female patient previously treated for GD. The patient underwent ultrasonography, computed tomography, inconclusive fine-needle aspiration, and ultimately gross dissection for diagnostic workup and definitive treatment of an anterior neck mass, producing a 2.5 \u00d7 2.3 \u00d7 1.5-cm entity consistent with Masaoka stage I and type B2 thymoma per World Health Organization classification. The patient underwent an uncomplicated subsequent clinical course, with no adjuvant radiotherapy administered. After conducting a systematic literature review, we conclude that of the 109 cases of ectopic cervical thymoma reported, this is the first to describe a case of ectopic cervical thymoma in a patient with a past medical history of GD. For GD patients in stable euthyroid remission with the persistent or recurrent presence of an anterior neck mass, the extrathyroidal origin of the mass should always be considered, including the exceptional presence of a cervical ectopic thymoma.<\/jats:p>","DOI":"10.1210\/clinem\/dgad635","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T13:48:59Z","timestamp":1698500939000},"page":"1198-1201","source":"Crossref","is-referenced-by-count":7,"title":["Ectopic Cervical Thymoma in a Patient Diagnosed With Graves Disease: A Systematic Literature Review"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0508-0711","authenticated-orcid":false,"given":"Samuel","family":"Nemiroff","sequence":"first","affiliation":[{"name":"Internal Medicine Resident at Mount Sinai Morningside and West , New York, NY 10019 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3582-4929","authenticated-orcid":false,"given":"Raymond","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilana","family":"Ramer-Bass","sequence":"additional","affiliation":[{"name":"Division of Endocrinology at Mount Sinai Morningside and West, Icahn School of Medicine at Mount Sinai , New York, NY 10019 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,10,28]]},"reference":[{"issue":"11","key":"2024041923071444700_dgad635-B1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/S0025-6196(12)60907-0","article-title":"Thymoma","volume":"68","author":"Morgenthaler","year":"1993","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"2024041923071444700_dgad635-B2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00428-016-1967-0","article-title":"The spectrum of ectopic thymomas","volume":"469","author":"Weissferdt","year":"2016","journal-title":"Virchows Arch"},{"issue":"8","key":"2024041923071444700_dgad635-B3","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1089\/thy.2017.0086","article-title":"Thymic hyperplasia associated with graves\u2019 disease: pathophysiology and proposed management algorithm","volume":"27","author":"Haider","year":"2017","journal-title":"Thyroid"},{"issue":"18","key":"2024041923071444700_dgad635-B4","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.2169\/internalmedicine.8710-21","article-title":"Graves\u2019 disease with thymic hyperplasia: the response of the thyroid function, thyrotropin receptor autoantibody, and thymic size to thiamazole treatment","volume":"61","author":"Tsukada","year":"2022","journal-title":"Intern Med"},{"issue":"12","key":"2024041923071444700_dgad635-B5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s40618-014-0157-7","article-title":"Thymic hyperplasia in patients with graves\u2019 disease","volume":"37","author":"Dalla Costa","year":"2014","journal-title":"J Endocrinol Invest"},{"key":"2024041923071444700_dgad635-B6","author":"Nemiroff"},{"issue":"12","key":"2024041923071444700_dgad635-B7","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.21037\/jtd-2019-thym-02","article-title":"Epidemiology of thymoma","volume":"12","author":"Rich","year":"2020","journal-title":"J Thorac Dis"},{"issue":"7","key":"2024041923071444700_dgad635-B8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.5631\/jibirin.98.577","article-title":"A case of thymoma in the neck: cervical thymoma","volume":"98","author":"Nagato","year":"2005","journal-title":"Pract Otol"},{"issue":"8","key":"2024041923071444700_dgad635-B9","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1634\/theoncologist.11-8-887","article-title":"Thymoma: benign appearance, malignant potential","volume":"11","author":"Riedel","year":"2006","journal-title":"Oncologist"},{"issue":"9","key":"2024041923071444700_dgad635-B10","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1097\/JTO.0000000000000300","article-title":"Paraneoplastic disorders in thymoma patients","volume":"9","author":"Evoli","year":"2014","journal-title":"J Thorac Oncol"},{"issue":"25","key":"2024041923071444700_dgad635-B11","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM199406233302507","article-title":"Myasthenia gravis","volume":"330","author":"Drachman","year":"1994","journal-title":"N Engl J Med"},{"key":"2024041923071444700_dgad635-B12","doi-asserted-by":"crossref","first-page":"bcr-2017-220153","DOI":"10.1136\/bcr-2017-220153","article-title":"Hickam\u2019s dictum: myasthenia gravis presenting concurrently with graves\u2019 disease","volume":"2017","author":"Sehgal","year":"2017","journal-title":"BMJ Case Rep"},{"issue":"2","key":"2024041923071444700_dgad635-B13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0049-0172(98)80039-5","article-title":"Malignant thymoma associated with autoinimune diseases: a retrospective study and review of the literature","volume":"28","author":"Levy","year":"1998","journal-title":"Semin Arthritis Rheum"},{"issue":"11","key":"2024041923071444700_dgad635-B14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2169\/internalmedicine.47.0838","article-title":"Malignant thymoma associated with myasthenia gravis, graves\u2019 disease, and SIADH","volume":"47","author":"Lee","year":"2008","journal-title":"Intern Med"},{"issue":"1","key":"2024041923071444700_dgad635-B15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1756-6614-5-5","article-title":"Mediastinal neoplasms in patients with graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia?","volume":"5","author":"Boyd","year":"2012","journal-title":"Thyroid Res"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgad635\/54945226\/dgad635.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/109\/5\/1198\/57285844\/dgad635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/109\/5\/1198\/57285844\/dgad635.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T23:09:04Z","timestamp":1713568144000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/109\/5\/1198\/7331844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,28]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10,28]]},"published-print":{"date-parts":[[2024,4,19]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgad635","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2023,10,28]]}}}