{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:09Z","timestamp":1792788309113,"version":"4.5.0"},"reference-count":60,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Capacity Building project of Local Colleges of Shanghai Science and Technology Commission","award":["23010502800"],"award-info":[{"award-number":["23010502800"]}]},{"name":"Shanghai Sailing Program","award":["22YF1417900"],"award-info":[{"award-number":["22YF1417900"]}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202240367"],"award-info":[{"award-number":["202240367"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Advanced glycation end products (AGEs) are a group of molecules formed through nonenzymatic reactions. These compounds are associated with several age-related diseases, including sarcopenia and osteoporosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to investigate the relationships between AGEs, osteoporosis, and sarcopenia in community-dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 1991 older adults aged 72.37 \u00b1 5.90 years from China. AGE levels were measured by the AGE Reader device. Bone mineral density was assessed using dual-energy X-ray absorptiometry, and osteoporosis was diagnosed based on a T score of less than \u22122.5. Sarcopenia was defined as loss of muscle mass plus loss of muscle strength and\/or reduced physical performance. Presarcopenia was defined as low muscle mass with normal muscle strength and normal physical performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of sarcopenia was 18.5%, and that of osteoporosis was 40.5%. Compared to the lowest AGE quartile, the highest AGE quartile showed a significant association with sarcopenia (odds ratio [OR] 2.42; 95% CI, 1.60-3.66) (P for trend &amp;lt;.001), but not with presarcopenia. Per-SD increase in AGE was associated with higher odds of sarcopenia (OR 1.44; 95% CI, 1.26-1.66). Additionally, in the mediation analysis, when AGEs were treated as a continuous variable (the mediation effect is denoted by Za*Zb = 18.81; 95% CI, 8.07-32.32]\u2014the 95% CI does not contain zero, representing a significant mediating effect) or a categorical variable (the mediating effect is expressed as Zmediation = 3.01 &amp;gt; 1.96, which represents a significant mediating effect), osteoporosis played a partial mediating role in the association between AGEs and sarcopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated AGEs are associated with sarcopenia but not with presarcopenia. This association was partially mediated by osteoporosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgad640","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T08:51:15Z","timestamp":1698483075000},"page":"e1105-e1116","source":"Crossref","is-referenced-by-count":14,"title":["Association Between Advanced Glycation End Products and Sarcopenia: The Mediating Role of Osteoporosis"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-6244","authenticated-orcid":false,"given":"Xingyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital , Shanghai 201318 , China"},{"name":"Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Institute of Sport, Exercise & Health, Tianjin University of Sport , Tianjin 300381 , 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