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Alterations in the ECS are linked to the development of cardiometabolic diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Here, we investigated the relationship between plasma levels of eCBs and their analogues with body composition and cardiometabolic risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study included 133 young adults (age 22.1 \u00b1 2.2 years, 67% women). Fasting plasma levels of eCBs and their analogues were measured using liquid chromatography-tandem mass spectrometry. Body composition, brown adipose tissue (BAT) volume, glucose uptake, and traditional cardiometabolic risk factors were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Plasma levels of eCBs and several eCB analogues were positively correlated with adiposity and traditional cardiometabolic risk factors (eg, serum insulin and triacylglyceride levels, all r \u2265 0.17 and P \u2264 .045). Plasma levels of 2-arachidonoyl glycerol and N-pentadecenoylethanolamine were negatively correlated with BAT volume and glucose uptake (all r \u2264 \u22120.17 and P \u2264 .047). We observed that the plasma levels of eCBs and their analogues were higher in metabolically unhealthy overweight\u2013obese participants than in metabolically healthy overweight\u2013obese participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings show that the plasma levels of eCBs and their analogues are related to higher levels of adiposity and worse cardiometabolic profile.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad668","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T16:57:42Z","timestamp":1699981062000},"page":"1351-1360","source":"Crossref","is-referenced-by-count":10,"title":["Higher Plasma Levels of Endocannabinoids and Analogues Correlate With a Worse Cardiometabolic Profile in Young Adults"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-9320","authenticated-orcid":false,"given":"Xinyu","family":"Di","sequence":"first","affiliation":[{"name":"Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research (LACDR), Leiden University , 2333 CC Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-1859","authenticated-orcid":false,"given":"Borja","family":"Martinez-Tellez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center , 2333 ZA Leiden , The Netherlands"},{"name":"PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada , 18071 Granada , Spain"},{"name":"SPORT Research Group, CERNEP Research Center, University of Almer\u00eda , 04120 Almer\u00eda , Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III , 18100 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke H J","family":"Krekels","sequence":"additional","affiliation":[{"name":"Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University , 2333 CC Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Jurado-Fasoli","sequence":"additional","affiliation":[{"name":"PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada , 18071 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria, ibs.Granada , 18012 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J","family":"Osuna-Prieto","sequence":"additional","affiliation":[{"name":"PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada , 18071 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria, ibs.Granada , 18012 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Ortiz-Alvarez","sequence":"additional","affiliation":[{"name":"PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada , 18071 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria, ibs.Granada , 18012 Granada , Spain"},{"name":"Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada , 18071 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-2073","authenticated-orcid":false,"given":"Thomas","family":"Hankemeier","sequence":"additional","affiliation":[{"name":"Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research (LACDR), Leiden University , 2333 CC Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-4988","authenticated-orcid":false,"given":"Patrick C N","family":"Rensen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center , 2333 ZA Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan R","family":"Ruiz","sequence":"additional","affiliation":[{"name":"PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada , 18071 Granada , Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III , 18100 Granada , Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria, ibs.Granada , 18012 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-1597","authenticated-orcid":false,"given":"Isabelle","family":"Kohler","sequence":"additional","affiliation":[{"name":"Division of BioAnalytical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam , 1081 HZ 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