{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:07:42Z","timestamp":1740136062669,"version":"3.37.3"},"reference-count":29,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K17313","22H03358"],"award-info":[{"award-number":["21K17313","22H03358"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Existing differences in persons with lower 30- or 60-minute plasma glucose (PG) levels during 75-g oral glucose tolerance test (OGTT) than fasting PG remain unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To clarify the characteristics of persons whose PG levels decrease after glucose administration during OGTT and their risk of incidence of diabetes in a Japanese general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this cohort study, a total of 3995 men and 3500 women (mean age 56.7 years) without diabetes were classified into 3 groups: (1) PG at both 30 and 60\u2005minutes \u2265 fasting PG; (2) PG at 30\u2005minutes \u2265 fasting PG and PG at 60\u2005minutes &amp;lt; fasting PG; (3) PG at 30\u2005minutes &amp;lt; fasting PG. The characteristics and the risk of diabetes onset were analyzed using ordered logistic regression and Cox proportional hazard regression, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 7495 participants, the numbers of individuals in the group 1, 2, and 3 were 6552, 769, and 174, respectively. The glucose response curve of the group 3 was boat shaped. Group 3 had the youngest age, lowest percentage of men, and best health condition, followed by groups 2 and 1. Among 3897 participants analyzed prospectively, 434 developed diabetes during the mean follow-up period of 5.8 years. The hazard ratio for diabetes onset in the group 2 was 0.30 with reference to the group 1. No-one in group 3 developed diabetes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>People with lower 30-minute PG than fasting PG tended to be women, young, healthy, and at low risk of diabetes onset.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad698","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T07:56:44Z","timestamp":1701331004000},"page":"e975-e982","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics and Risk of Diabetes in People With Rare Glucose Response Curve During an Oral Glucose Tolerance Test"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4933-3514","authenticated-orcid":false,"given":"Yukako","family":"Tatsumi","sequence":"first","affiliation":[{"name":"Department of Hygiene and Public Health, Teikyo University School of Medicine , Tokyo 173-8605 , Japan"},{"name":"Open Innovation Center, National Cerebral and Cardiovascular Center , Suita 564-8565 , Japan"},{"name":"Department of Clinical Nursing, Shiga University of Medical Science , Otsu 520-2192 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1337-0508","authenticated-orcid":false,"given":"Yoshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Open Innovation Center, National Cerebral and Cardiovascular Center , Suita 564-8565 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-0547","authenticated-orcid":false,"given":"Kei","family":"Asayama","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health, Teikyo University School of Medicine , Tokyo 173-8605 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-1239","authenticated-orcid":false,"given":"Michihiro","family":"Satoh","sequence":"additional","affiliation":[{"name":"Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University , Sendai 983-8536 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7670-3614","authenticated-orcid":false,"given":"Naomi","family":"Miyamatsu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nursing, Shiga University of Medical Science , Otsu 520-2192 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-6793","authenticated-orcid":false,"given":"Yuko","family":"Ohno","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Osaka University Graduate School of Medicine , Suita 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Ikei","sequence":"additional","affiliation":[{"name":"Department of Health Checkup, Saku Central Hospital , Saku 384-0301 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-8196","authenticated-orcid":false,"given":"Takayoshi","family":"Ohkubo","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health, Teikyo University School of Medicine , Tokyo 173-8605 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,12,1]]},"reference":[{"issue":"10","key":"2024022001115291900_dgad698-B1","first-page":"1041","article-title":"Analysis of biphasic blood glucose curves during oral glucose tolerance test in normal subjects","volume":"26","author":"Morita","year":"1983","journal-title":"J. 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