{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:16:14Z","timestamp":1793412974656,"version":"4.5.0"},"reference-count":36,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005131","name":"HRB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Gestational diabetes mellitus (GDM) is a complex obstetric condition affecting localized glucose metabolism, resulting in systemic metabolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This cross-sectional study aimed to explore visceral adipose tissue (VAT) as an integral contributor to GDM, focusing on elucidating the specific contribution of obesity and GDM pathology to maternal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-six nulliparous pregnant women were recruited, including normal glucose tolerant (NGT) (n = 30) and GDM (n = 26) participants. Participants were subgrouped as nonobese (BMI &amp;lt;30\u2005kg\/m2) or obese (BMI \u226530\u2005kg\/m2). Metabolic markers in circulation, VAT, and placenta were determined. Morphological analysis of VAT and immunoblotting of the insulin signaling cascade were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GDM participants demonstrated hyperinsulinemia and elevated homeostatic model assessment for insulin resistance (HOMA-IR) scores relative to NGT participants. The GDM-obese subgroup had significant VAT adipocyte hypoplasia relative to NGT-nonobese tissue. GDM-obese VAT had significantly lower insulin receptor substrate (IRS)-2 expression, with elevated ser312 phosphorylation of IRS-1, relative to NGT-nonobese. GDM-obese participants had significantly elevated circulating leptin levels and placental adipsin secretion, while GDM-nonobese participants had elevated circulating adipsin levels with reduced placental adiponectin secretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that GDM-obese pregnancy is specifically characterized by inadequate VAT remodeling and dysfunctional molecular signaling, which contribute to insulin resistance and hinder metabolic health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgad699","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T19:14:59Z","timestamp":1701198899000},"page":"1275-1284","source":"Crossref","is-referenced-by-count":9,"title":["Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus"],"prefix":"10.1210","volume":"109","author":[{"given":"Colm J","family":"McElwain","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Western Gateway Building, University College Cork , Cork T12XF62 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samprikta","family":"Manna","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Cork University Maternity Hospital , Cork T12DC4A , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Musumeci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Western Gateway Building, University College Cork , Cork T12XF62 , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Sylvester","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, Western Gateway Building, University College Cork , 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