{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:10:42Z","timestamp":1790604642290,"version":"4.1.0"},"reference-count":41,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100013394","name":"Instituto Nacional de Medicina Gen\u00f3mica","doi-asserted-by":"publisher","award":["10\/2016\/I"],"award-info":[{"award-number":["10\/2016\/I"]}],"id":[{"id":"10.13039\/501100013394","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Pancreatic \u03b2-cell function impairment is a key mechanism for developing gestational diabetes mellitus (GDM). Maternal and placental exosomes regulate maternal and placental responses during hyperglycemia. Studies have associated exosomal micro-RNAs (miRNAs) with GDM development. To date, no studies have been reported that evaluate the profile of miRNAs present in maternal and placental exosomes in the early stages of gestation from pregnancies that develop GDM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We assessed whether early-pregnancy serum maternal and placenta-derived exosomes miRNA profiles vary according to pancreatic \u03b2-cell function in women who will develop GDM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective nested case\u2013control study was used to identify exosomal miRNAs that vary in early-pregnancy stages (&amp;lt;18 weeks of gestation) from women with normoglycemia and those who developed GDM based on their pancreatic \u03b2-cell function using the homeostasis model assessment of pancreatic \u03b2-cell function (HOMA-%\u03b2) index. Early-pregnancy serum maternal and placenta-derived exosomes were isolated to obtain miRNA profiles. Potential target and pathway analyses were performed to identify molecular and metabolic pathways associated with the exosomal miRNAs identified.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In early-pregnancy stages, serum maternal exosome size and concentration are modified in GDM group and fluctuate according to HOMA-%\u03b2 index. Serum maternal exosomal hsa-miR-149-3p and hsa-miR-455-3p in GDM are related to insulin secretion and signaling, lipolysis, and adipocytokine signaling. Early-pregnancy serum placenta-derived exosomes hsa-miR-3665 and hsa-miR-6727-5p in GDM are related to regulating genes involved in response to immunological tolerance of pregnancy and pathways associated with placental dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Early serum exosomal miRNAs differ depending on their origin (maternal or placental) and pancreatic \u03b2-cell function. This research provides insights into the interactions between maternal and placental exosomal miRNAs and may have implications for identifying potential biomarkers or therapeutic targets for GDM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad751","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T20:58:45Z","timestamp":1703192325000},"page":"1526-1539","source":"Crossref","is-referenced-by-count":13,"title":["Early-Pregnancy Serum Maternal and Placenta-Derived Exosomes miRNAs Vary Based on Pancreatic \u03b2-Cell Function in GDM"],"prefix":"10.1210","volume":"109","author":[{"given":"Melissa","family":"Razo-Azamar","sequence":"first","affiliation":[{"name":"Laboratorio de Envejecimiento Saludable del Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN) en el Centro de Investigaci\u00f3n sobre Envejecimiento (CIE-CINVESTAV Sede Sur) , 14330 CDMX , M\u00e9xico"},{"name":"Departamento de Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , 14080 CDMX , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Nambo-Venegas","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica de Enfermedades Cr\u00f3nicas Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN) , 14610 CDMX , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n Rafael","family":"Quevedo","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica Industrial y de Alimentos (DIQIA), Universidad Iberoamericana Ciudad de M\u00e9xico (UIA) , 01219 CDMX , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Ju\u00e1rez-Luna","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica Industrial y de Alimentos (DIQIA), Universidad Iberoamericana Ciudad de M\u00e9xico (UIA) , 01219 CDMX , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4474-0046","authenticated-orcid":false,"given":"Carlos","family":"Salomon","sequence":"additional","affiliation":[{"name":"Translational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland , Brisbane, QLD 4029 , Australia"},{"name":"Departamento de Investigaci\u00f3n, Postgrado y Educaci\u00f3n Continua (DIPEC), Facultad de Ciencias de la Salud, Universidad del Alba , 8320000 Santiago , Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-3481","authenticated-orcid":false,"given":"Martha","family":"Guevara-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda de la Nutrici\u00f3n, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , 14080 CDMX , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7848-1532","authenticated-orcid":false,"given":"Berenice","family":"Palacios-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Laboratorio de Envejecimiento Saludable del Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN) en el Centro de Investigaci\u00f3n sobre Envejecimiento (CIE-CINVESTAV Sede Sur) , 14330 CDMX , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"issue":"Suppl 1","key":"2024051707033858000_dgad751-B1","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.2337\/dc23-S002","article-title":"2. 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