{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T03:30:19Z","timestamp":1782358219565,"version":"3.54.5"},"reference-count":45,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish state"},{"name":"Swedish government"},{"name":"County Councils"},{"name":"ALF-agreement","award":["ALFGBG-719531"],"award-info":[{"award-number":["ALFGBG-719531"]}]},{"name":"ALF-agreement","award":["ALFGBG-772591"],"award-info":[{"award-number":["ALFGBG-772591"]}]},{"name":"ALF-agreement","award":["ALFGBG-966066"],"award-info":[{"award-number":["ALFGBG-966066"]}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["21 1774 Pj"],"award-info":[{"award-number":["21 1774 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health & Medical Care Committee"},{"name":"V\u00e4stra G\u00f6taland Region, Sweden","award":["VGFOUREG-929693"],"award-info":[{"award-number":["VGFOUREG-929693"]}]},{"DOI":"10.13039\/501100007687","name":"The Swedish Society of Medicine","doi-asserted-by":"publisher","award":["SLS-884901"],"award-info":[{"award-number":["SLS-884901"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>There is a lack of reliable biomarkers capable of predicting postoperative tumor progression of nonfunctioning pituitary adenomas (NFPAs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To discover proteomic profiles associated with postoperative tumor progression in patients with NFPAs. This was a case-controlled exploratory study at a tertiary university hospital. Tissue samples were obtained from 46 patients with residual tumor following surgery for NFPAs of gonadotroph lineage. Two patient groups were compared: patients requiring reintervention due to residual tumor progression (cases; reintervention group, n = 29) and patients with a residual tumor showing no progression for a minimum of 5 years (controls; radiologically stable group, n = 17). Differentially expressed proteins (DEPs) between patient groups were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Global quantitative proteomic analysis identified 4074 proteins, of which 550 were differentially expressed between the 2 groups (fold change &amp;gt;80%, false discovery rate\u2013adjusted P \u2264 .05). Principal component analysis showed good separation between the 2 groups. Functional enrichment analysis of the DEPs indicated processes involving translation, ROBO-receptor signaling, energy metabolism, mRNA metabolism, and RNA splicing. Several upregulated proteins in the reintervention group, including SNRPD1, SRSF10, SWAP-70, and PSMB1, are associated with tumor progression in other cancer types.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This is the first exploratory study analyzing proteomic profiles as markers of postoperative tumor progression in NFPAs. The findings clearly showed different profiles between tumors with indolent postoperative behavior and those with postoperative tumor progression. Both enriched pathways involving DEPs and specific upregulated proteins have previously been associated with tumor aggressiveness. These results suggest the value of proteomic profiling for predicting tumor progression in patients with NFPAs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad767","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T23:25:06Z","timestamp":1703805906000},"page":"1485-1493","source":"Crossref","is-referenced-by-count":8,"title":["Proteomic Profiles Associated With Postsurgical Progression in Nonfunctioning Pituitary Adenomas"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-7686","authenticated-orcid":false,"given":"Tobias","family":"Hall\u00e9n","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Sahlgrenska University Hospital , 412 65 Gothenburg , Sweden"},{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg , 405 30 Gothenburg , 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