{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:51:15Z","timestamp":1785498675995,"version":"3.56.0"},"reference-count":43,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013104","name":"Shanghai Health and Medical Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013104","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Education Commission-Gaofeng Clinical Medicine","award":["20181807"],"award-info":[{"award-number":["20181807"]}]},{"name":"Science and Technology Commission of Shanghai Municipality-Science and Technology Program","award":["20DZ2201500"],"award-info":[{"award-number":["20DZ2201500"]}]},{"DOI":"10.13039\/501100020771","name":"Young Scientists Fund of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100864"],"award-info":[{"award-number":["82100864"]}],"id":[{"id":"10.13039\/501100020771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20204Y0294"],"award-info":[{"award-number":["20204Y0294"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202240107"],"award-info":[{"award-number":["202240107"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program-Youth Medical Talents-Specialist Program","award":["2022"],"award-info":[{"award-number":["2022"]}]},{"name":"Natural Science Foundation of Minhang District, Shanghai, China","award":["2021MHZ2020"],"award-info":[{"award-number":["2021MHZ2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Sugar alcohols (also called polyols) are regarded as a \u201chealthy\u201d sugar substitute. One of the possible reasons for their safe use in pregnant women is their natural origin and the presence of polyols in maternal and fetal samples during normal human gestation. But little is known about the association between circulating sugar alcohols levels and maternal metabolic disorders during pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to detect the concentration of the polyols in participants with and without gestational diabetes mellitus (GDM), and to investigate the association between maternal serum levels of polyols and GDM, as well as newborn outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A nested population-based case\u2013control study was conducted in 109 women with and without GDM. Maternal concentrations of serum erythritol, sorbitol, and xylitol in the fasting state were quantified using a time of flight mass spectrometry system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Result<\/jats:title>\n                  <jats:p>In women with GDM, serum concentrations of erythritol and sorbitol were higher, but serum concentrations of xylitol were lower than those in women without GDM. Per 1-SD increment of Box\u2013Cox-transformed concentrations of erythritol and sorbitol were associated with the increased odds of GDM by 43% and 155% (95% CI 1.07-1.92 and 95% CI 1.77-3.69), while decreased odds were found for xylitol by 25% (95% CI 0.57-1.00). Additionally, per 1-SD increase of Box\u2013Cox-transformed concentrations of serum sorbitol was associated with a 52% increased odds of large for gestational age newborns controlling for possible confounders (95% CI 1.00-2.30).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Maternal circulating sugar alcohols levels during pregnancy were significantly associated with GDM. These findings provide the potential roles of polyols on maternal metabolic health during pregnancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae002","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T14:27:28Z","timestamp":1704724048000},"page":"1858-1865","source":"Crossref","is-referenced-by-count":2,"title":["Maternal Serum Polyols and Its Link to Gestational Diabetes Mellitus: A Population-Based Nested Case\u2013Control Study"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4678-8541","authenticated-orcid":false,"given":"Xiaoyong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5100-244X","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chongming Hospital Affiliated to Shanghai University of Health & Medicine Sciences (Chongming Branch of Xinhua Hospital) , Shanghai 202150 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Pujiang Community Health Service Center , Minhang District, Shanghai 201112 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1098-945X","authenticated-orcid":false,"given":"Jing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200127 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-2266","authenticated-orcid":false,"given":"Li","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200092 , China"},{"name":"Department of Endocrinology, Chongming Hospital Affiliated to Shanghai University of Health & Medicine Sciences (Chongming Branch of Xinhua Hospital) , Shanghai 202150 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"issue":"1","key":"2024061623511236600_dgae002-B1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/eurpub\/cky087","article-title":"The impact of a sugar-sweetened beverages tax on oral health and costs of dental care in Australia","volume":"29","author":"Sowa","year":"2019","journal-title":"Eur J Public Health"},{"issue":"1","key":"2024061623511236600_dgae002-B2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/0022034517736499","article-title":"Erythritol functional roles in oral-systemic health","volume":"29","author":"de Cock","year":"2018","journal-title":"Adv Dent Res"},{"key":"2024061623511236600_dgae002-B3","author":"High-Intensity Sweeteners"},{"issue":"Supplement 1","key":"2024061623511236600_dgae002-B4","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.2337\/dc23-S005","article-title":"5. 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