{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:32:37Z","timestamp":1784291557048,"version":"3.55.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100007660","name":"University of Antwerp","doi-asserted-by":"publisher","award":["BOF, Antigoon ID: 44430"],"award-info":[{"award-number":["BOF, Antigoon ID: 44430"]}],"id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Belgian Association for the study of the Liver"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Insulin resistance (IR) is increasingly more prevalent in people with type 1 diabetes (T1D).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We investigated whether IR is associated with continuous glucose monitor (CGM)-derived parameters (glucometrics), such as time in range (TIR), time above range (TAR), time below range (TBR), and glycemic variability (CV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a retrospective analysis of 2 databases: IR was quantified according to the estimated glucose disposal rate (eGDR) (NCT04664036) and by performing a hyperinsulinemic-euglycemic clamp (HEC) (NCT04623320). All glucometrics were calculated over 28 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 287 subjects were included. Mean age was 46 \u00b1 17 years, 55% were male, TIR was 57% \u00b1 14%, and eGDR was 7.6 (5.6-9.3) mg\/kg\/min. The tertile of people with the lowest eGDR (highest level of IR) had a higher TAR compared to the tertile with the highest eGDR (39% \u00b1 15% vs 33% \u00b1 14%, P = .043). Using logistic regression, a higher eGDR was associated with a higher chance to fall in a higher TIR-tertile (odds ratio [OR] 1.251, P &amp;lt; .001), a lower TAR-tertile (OR 1.281, P &amp;lt; .001), and a higher TBR-tertile (OR 0.893, P = .039), adjusted for age, sex, diabetes duration, smoking status, and alcohol intake. In the 48 people undergoing a HEC, no significant association between glucometrics and the HEC-determined glucose disposal rate (M-value) was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In people with T1D, an association between IR, measured by eGDR, and worse CGM profiles was observed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae015","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T23:32:02Z","timestamp":1704929522000},"page":"e2131-e2140","source":"Crossref","is-referenced-by-count":12,"title":["Insulin Resistance and CGM-Derived Parameters in People With Type 1 Diabetes: Are They Associated?"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3652-4733","authenticated-orcid":false,"given":"Isabel","family":"Clinck","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital , 2650 Edegem ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4822-4113","authenticated-orcid":false,"given":"Jonathan","family":"Mertens","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital , 2650 Edegem ,","place":["Belgium"]},{"name":"Laboratory of Experimental Medicine and Paediatrics and member of the Infla-Med Centre of Excellence, University of Antwerp, Faculty of Medicine & Health Sciences , 2000 Antwerp ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9263-186X","authenticated-orcid":false,"given":"Kristien","family":"Wouters","sequence":"additional","affiliation":[{"name":"Clinical Trial Centre (CTC), CRC Antwerp, Antwerp University Hospital , 2650 Edegem 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