{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:25:12Z","timestamp":1784204712355,"version":"3.55.0"},"reference-count":41,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>There are only a few nationwide studies on boys with central precocious puberty (CPP) and the last Italian study is a case series of 45 boys that dates back to 2000.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to evaluate the causes of CPP in boys diagnosed during the last 2 decades in Italy and the relative frequency of forms with associated central nervous system (CNS) abnormalities on magnetic resonance imaging (MRI) compared to idiopathic ones.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a national multicenter retrospective study collecting data from 193 otherwise normal healthy boys with a diagnosis of CPP. Based on MRI findings, the patients were divided into: Group 1, no CNS abnormalities; Group 2, mild abnormalities (incidental findings) unrelated to CPP; and Group 3, causal pathological CNS abnormalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The MRI findings show normal findings in 86%, mild abnormalities (incidental findings) in 8.3%, and causal pathological CNS abnormalities in 5.7% of the cases. In Group 3, we found a higher proportion of patients with chronological age at diagnosis &amp;lt;\u202f7 years (P = .00001) and body mass index greater than +2 SDS (P &amp;lt; .01). Gonadotropin-releasing hormone analogue therapy was started in 183\/193 subjects. The final height appeared in the range of the target height in all groups and in 9 patients in whom the therapy was not started.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In our study on a large nationwide cohort of boys referred for precocious puberty signs, the percentage of forms associated with CNS abnormalities was one of the lowest reported in the literature.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae035","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T12:56:37Z","timestamp":1706792197000},"page":"2061-2070","source":"Crossref","is-referenced-by-count":20,"title":["Central Precocious Puberty in Italian Boys: Data From a Large Nationwide Cohort"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3048-4531","authenticated-orcid":false,"given":"Alessandra","family":"Cassio","sequence":"first","affiliation":[{"name":"Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , 40138 Bologna , Italy"},{"name":"Department of Medical and Surgery Sciences, University of Bologna , 40138 Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Marescotti","sequence":"additional","affiliation":[{"name":"Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , 40138 Bologna , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Aversa","sequence":"additional","affiliation":[{"name":"Department of Human Pathology of Adulthood and Childhood, University of Messina , 98125 Messina , Italy"},{"name":"Pediatric Unit, University Hospital , 98122 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-3300","authenticated-orcid":false,"given":"Mariacarolina","family":"Salerno","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Unit, Department of Translational Medical Sciences, University Federico II , 80131 Naples , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4395-3915","authenticated-orcid":false,"given":"Gianluca","family":"Tornese","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS \u201cBurlo Garofolo\u201d , 34137 Trieste , Italy"},{"name":"Department of Medicine, Surgery and Health Sciences, University of Trieste , 34129 Trieste , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Stancampiano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Endocrine Unit, IRCCS San Raffaele Scientific Institute , 20132 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerdi","family":"Tuli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Regina Margherita Children's Hospital, Department of Pediatric Sciences, University of Turin , 10126 Torino , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Felicia","family":"Faienza","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari \u201cA. Moro\u201d , 70124 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Cavarzere","sequence":"additional","affiliation":[{"name":"Pediatric Division, Department of Pediatrics, University Hospital of Verona , 37126 Verona , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-6501","authenticated-orcid":false,"given":"Daniela","family":"Fava","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa 16142 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Parpagnoli","sequence":"additional","affiliation":[{"name":"Department of Diabetology and Endocrinology, Meyer Children Hospital IRCCS , 50139 Florence , 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