{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:46:13Z","timestamp":1778168773040,"version":"3.51.4"},"reference-count":14,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To test the ability of the 2015 modified version of the European Network for the Study of Adrenal Tumors staging system (mENSAT) in predicting cancer-specific mortality (CSM), as well as overall mortality (OM) in adrenocortical carcinoma (ACC) patients of all stages, in a large-scale, and contemporary United States cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We relied on the Surveillance, Epidemiology, and End Results (SEER) database (2004\u20132020) to test the accuracy and calibration of the mENSAT and subsequently compared it to the 8th edition of the American Joint Committee on Cancer staging system (AJCC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 858 ACC patients, mENSAT accuracy was 74.7% for 3-year CSM predictions and 73.8% for 3-year OM predictions. The maximum departures from ideal predictions in mENSAT were +17.2% for CSM and +11.8% for OM. Conversely, AJCC accuracy was 74.5% for 3-year CSM predictions and 73.5% for 3-year OM predictions. The maximum departures from ideal predictions in AJCC were \u22126.7% for CSM and \u22127.1% for OM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The accuracy of mENSAT is virtually the same as that of AJCC in predicting CSM (74.7% vs 74.5%) and OM (73.7% vs 73.5%). However, calibration is lower for mENSAT than for AJCC. In consequence, no obvious benefit appears to be associated with the use of mENSAT relative to AJCC in US ACC patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae047","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:05:55Z","timestamp":1706141155000},"page":"e2084-e2089","source":"Crossref","is-referenced-by-count":3,"title":["The European Network for the Study of Adrenal Tumors Staging System (2015): A United States Validation"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0612-0519","authenticated-orcid":false,"given":"Letizia Maria Ippolita","family":"Jannello","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montr\u00e9al Health Center , Montr\u00e9al, Qu\u00e9bec, H2X 0A9 ,","place":["Canada"]},{"name":"Department of Urology, IEO European Institute of Oncology, IRCCS , Milan, 20141 ,","place":["Italy"]},{"name":"Department of Urology, Universit\u00e0 degli Studi di Milano , Milan, 20122 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-2274","authenticated-orcid":false,"given":"Reha-Baris","family":"Incesu","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montr\u00e9al Health Center , Montr\u00e9al, Qu\u00e9bec, H2X 0A9 ,","place":["Canada"]},{"name":"Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf , Hamburg, 20251 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Morra","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montr\u00e9al Health Center , Montr\u00e9al, Qu\u00e9bec, H2X 0A9 ,","place":["Canada"]},{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II , Naples, 80131 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-8438","authenticated-orcid":false,"given":"Lukas","family":"Scheipner","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montr\u00e9al Health Center , Montr\u00e9al, Qu\u00e9bec, H2X 0A9 ,","place":["Canada"]},{"name":"Department of Urology, Medical University of Graz , Graz, 8010 ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0746-2876","authenticated-orcid":false,"given":"Andrea","family":"Baudo","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montr\u00e9al Health Center , Montr\u00e9al, Qu\u00e9bec, H2X 0A9 ,","place":["Canada"]},{"name":"Department of Urology, Universit\u00e0 degli Studi di Milano , Milan, 20122 ,","place":["Italy"]},{"name":"Department of Urology, IRCCS Policlinico San Donato , Milan, 20097 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"de Angelis","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montr\u00e9al Health Center , Montr\u00e9al, Qu\u00e9bec, H2X 0A9 ,","place":["Canada"]},{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute , Milan, 20132 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5460-4171","authenticated-orcid":false,"given":"Carolin","family":"Siech","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montr\u00e9al Health Center , Montr\u00e9al, Qu\u00e9bec, H2X 0A9 ,","place":["Canada"]},{"name":"Department of Urology, University Hospital Frankfurt, Goethe University Frankfurt am Main , Frankfurt am Main, 60629 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montr\u00e9al Health Center , Montr\u00e9al, Qu\u00e9bec, H2X 0A9 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan A","family":"Goyal","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montr\u00e9al Health Center , Montr\u00e9al, Qu\u00e9bec, H2X 0A9 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