{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:46:46Z","timestamp":1787021206776,"version":"build-2736575974"},"reference-count":32,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Health Ministry","award":["RC 2021-2022-2023"],"award-info":[{"award-number":["RC 2021-2022-2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Current evidence of cardiovascular (CV) risk in primary hyperparathyroidism (PHPT) is still inconsistent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To prospectively investigate changes of early atherosclerosis in patients with PHPT undergoing parathyroidectomy (PTx) or conservative management, according to consensus criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Biochemical parameters of PHPT, CV risk factors (systolic and diastolic blood pressure, cholesterol [total, high-density, and low-density], triglyceride, HbA1c, HOMA-IR), and carotid intima-media thickness (IMT) and plaque were assessed in 52 consecutive postmenopausal PHPT patients both at baseline and \u2265\u202f24\u2005months after surgery (PTx, n = 22) or conservative management (non-PTx, n = 30).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, PTx and non-PTx showed comparable age, BMI, renal function, and 25(OH)D levels, and did not differ for CV risk factors, IMT and plaques, or for prevalence of smoking, diabetes mellitus, or antihypertensive or statin therapy, while all parameters characterizing PHPT differed. Follow-up duration in PTx was longer than in non-PTx (P = .004). Parameters characterizing PHPT significantly improved \u2265\u202f24\u2005months after surgery, whereas in non-PTx serum phosphate slightly decreased and parathyroid hormone increased. Systolic and diastolic blood pressure increased at follow-up in both groups, while other CV risk factors did not significantly vary. In PTx, IMT did not significantly vary after surgery (0.85 \u00b1 0.14 to 0.89 \u00b1 0.22\u2005mm, P = .366), whereas it significantly increased in non-PTx (0.80 \u00b1 0.18 to 0.93 \u00b1 0.23\u2005mm, P = .008), even adjusting for blood pressure. Plaque prevalence and incidence did not significantly differ in the 2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that in postmenopausal patients with PHPT, subclinical atherosclerosis could be halted by PTx, whereas it worsens over time in nonoperated patients with milder disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgae053","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T16:28:49Z","timestamp":1707496129000},"page":"e2342-e2347","source":"Crossref","is-referenced-by-count":6,"title":["Carotid Intima-Media Thickness in Surgically or Conservatively Managed Patients With Primary Hyperparathyroidism"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-1278","authenticated-orcid":false,"given":"Vincenzo","family":"Carnevale","sequence":"first","affiliation":[{"name":"Unit of Internal Medicine, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS , 71013 San Giovanni Rotondo, FG ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS , 71013 San Giovanni Rotondo, FG ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Eller-Vainicher","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS \u201cCa\u2019 Granda Ospedale Maggiore Policlinico , 20122 Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio S","family":"Salcuni","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Metabolism, University-Hospital S. Maria Della Misericordia , 33100 Udine ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Nieddu","sequence":"additional","affiliation":[{"name":"Department of Humanistic and International Social Sciences, UNINT University , 00147 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7594-3300","authenticated-orcid":false,"given":"Iacopo","family":"Chiodini","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, Ospedale Niguarda C\u00e0 Granda , 20112 Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Scillitani","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS , 71013 San Giovanni Rotondo, FG ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"issue":"11","key":"2024111804011208100_dgae053-B1","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1002\/jbmr.4679","article-title":"Classical and nonclassical manifestations of primary hyperparathyroidism","volume":"37","author":"El-Hajj-Fuleihan","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2024111804011208100_dgae053-B2","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/BF03346443","article-title":"Cardiovascular aspects of primary hyperparathyroidism","volume":"31","author":"Walker","year":"2008","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"2024111804011208100_dgae053-B3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.beem.2018.06.006","article-title":"Non classical complications of primary hyperparathyroidism","volume":"32","author":"Chiodini","year":"2018","journal-title":"Best Pract & Res Clin Endocrinol Metab"},{"issue":"4","key":"2024111804011208100_dgae053-B4","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.numecd.2020.12.029","article-title":"Impact of parathyroidectomy on cardiovascular risk in primary hyperparathyroidism: a narrative review","volume":"31","author":"Frey","year":"2021","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"6","key":"2024111804011208100_dgae053-B5","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1161\/01.CIR.74.6.1399","article-title":"Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging","volume":"74","author":"Pignoli","year":"1986","journal-title":"Circulation"},{"issue":"10","key":"2024111804011208100_dgae053-B6","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jcmg.2013.11.014","article-title":"Carotid intima-media thickness and plaque in cardiovascular risk assessment","volume":"7","author":"Naqvi","year":"2014","journal-title":"J Am Coll Cardiol Cardiovasc Imaging"},{"issue":"1","key":"2024111804011208100_dgae053-B7","doi-asserted-by":"crossref","first-page":"e005313","DOI":"10.1161\/JAHA.116.005313","article-title":"Carotid intima-media thickness and prediction of cardiovascular disease","volume":"6","author":"\u00d8ygarden","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"5","key":"2024111804011208100_dgae053-B8","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/01.ATV.11.5.1245","article-title":"Ultrasonographically assessed carotid morphology and the risk of coronary heart disease","volume":"11","author":"Salonen","year":"1991","journal-title":"Arterioscl Thromb"},{"issue":"4","key":"2024111804011208100_dgae053-B9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/CIRCULATIONAHA.106.628875","article-title":"Prediction of clinical cardiovascular event with carotid intima-media thickness. 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