{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:32:30Z","timestamp":1788474750414,"version":"build-2803163510"},"reference-count":42,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007835","name":"Silesian University of Technology","doi-asserted-by":"publisher","award":["02\/080\/SDU\/10-21-01"],"award-info":[{"award-number":["02\/080\/SDU\/10-21-01"]}],"id":[{"id":"10.13039\/501100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007835","name":"Silesian University of Technology","doi-asserted-by":"publisher","award":["07\/010\/BKM23\/1028"],"award-info":[{"award-number":["07\/010\/BKM23\/1028"]}],"id":[{"id":"10.13039\/501100007835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>The presence of metabolic dysfunction\u2013associated steatotic liver disease (MASLD) in patients with diabetes mellitus (DM) is associated with a high risk of cardiovascular disease, but is often underdiagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop machine learning (ML) models for risk assessment of MASLD occurrence in patients with DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Feature selection determined the discriminative parameters, utilized to classify DM patients as those with and without MASLD. The performance of the multiple logistic regression model was quantified by sensitivity, specificity, and percentage of correctly classified patients, and receiver operating characteristic (ROC) curve analysis. Decision curve analysis (DCA) assessed the model's net benefit for alternative treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We studied 2000 patients with DM (mean age 58.85 \u00b1 17.37 years; 48% women). Eight parameters: age, body mass index, type of DM, alanine aminotransferase, aspartate aminotransferase, platelet count, hyperuricaemia, and treatment with metformin were identified as discriminative. The experiments for 1735 patients show that 744\/991 (75.08%) and 586\/744 (78.76%) patients with\/without MASLD were correctly identified (sensitivity\/specificity: 0.75\/0.79). The area under ROC (AUC) was 0.84 (95% CI, 0.82-0.86), while DCA showed a higher clinical utility of the model, ranging from 30% to 84% threshold probability. Results for 265 test patients confirm the model's generalizability (sensitivity\/specificity: 0.80\/0.74; AUC: 0.81 [95% CI, 0.76-0.87]), whereas unsupervised clustering identified high-risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A ML approach demonstrated high performance in identifying MASLD in patients with DM. This approach may facilitate better risk stratification and cardiovascular risk prevention strategies for high-risk patients with DM at risk of MASLD.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgae060","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T20:22:33Z","timestamp":1707423753000},"page":"2029-2038","source":"Crossref","is-referenced-by-count":17,"title":["Machine Learning Identifies Metabolic Dysfunction\u2013Associated Steatotic Liver Disease in Patients With Diabetes Mellitus"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0777-8048","authenticated-orcid":false,"given":"Katarzyna","family":"Nabrdalik","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia , 40-055 Katowice , Poland"},{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John 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