{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:09:03Z","timestamp":1791828543273,"version":"4.3.4"},"reference-count":53,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To conduct a systematic review (SR) and meta-analysis (MA) on health-related quality-of-life (QoL) and associated factors among children\/adolescents with congenital adrenal hyperplasia (CAH).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Following registration in the PROSPERO International Prospective Register of Systematic Reviews(reg no: CRD42022313389), Google Scholar, PubMed, LILACS, Cochrane, and Scopus databases were searched up to March 5, 2022, using predefined search strategy\/MESH terms to identify original studies describing\/assessing self-reported\/parent-reported health-related QoL in patients with CAH \u226421 years. Methodological quality was assessed by Newcastle-Ottawa Quality Assessment Scale (NOS), and heterogeneity by I2 statistics. MA assessed mean difference (MD) in QoL between children\/adolescents with CAH and healthy children\/adolescents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 1308 publications, the 12 studies eligible for the SR (CAH n = 781) showed NOS scales of 3 to 7\/9, and the 6 eligible for MA (CAH n = 227) showed moderate-considerable heterogeneity. MA showed that parent-reported psychosocial QoL (MD 9.9 [\u221212.6,7.3], P \u2264 .001) {consisting of school (MD 7.4[\u221212.2, \u22122.5], P = .003), emotional (MD 5.6 [\u221210.2, \u22120.9], P = .02) and social domains (MD 4.3 [\u22128.1, \u22120.5], P = .03), and self-reported school domain QoL (MD 8.5 [\u221215.9, \u22121.2], P = .02) was lower in children\/adolescents with CAH while parent-reported and self-reported physical QoL were similar to controls.<\/jats:p>\n                  <jats:p>Factors associated with lower QoL among children\/ adolescents with CAH included poor disease control, poor medication compliance, and complications including hyperpigmentation, virilization, hypertension, hospital admission, and urinary incontinence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Based on available data, children\/adolescents with CAH had preserved physical QoL but impaired psychosocial QoL, especially in the school domain. Factors associated with lower QoL included poor disease control and disease\/treatment-related complications. There is a need for further high-quality research that investigates the relationship between disease control, provision of psychosocial support, and improvement in QoL in children\/adolescents with CAH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae068","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T08:36:32Z","timestamp":1707467792000},"page":"1618-1629","source":"Crossref","is-referenced-by-count":14,"title":["Health-Related Quality of Life in Children and Adolescents With Congenital Adrenal Hyperplasia: A Systematic Review and Meta-Analysis"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-262X","authenticated-orcid":false,"given":"Shamaali","family":"Gunawardana","sequence":"first","affiliation":[{"name":"Postgraduate Institute of Medicine , University of Colombo, Colombo , Sri 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