{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:33:46Z","timestamp":1790822026925,"version":"4.1.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"11","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009128","name":"Research for Patient Benefit (RfPB) Programme","doi-asserted-by":"publisher","award":["Grant Reference Number PB-PG-1111-26003"],"award-info":[{"award-number":["Grant Reference Number PB-PG-1111-26003"]}],"id":[{"id":"10.13039\/501100009128","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Southampton NIHR Biomedical Research Centre, UK","award":["IS-BRC-1215-20004"],"award-info":[{"award-number":["IS-BRC-1215-20004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Low birth weight, as seen in Silver-Russell syndrome (SRS), is associated with later cardiometabolic disease. Data on long-term outcomes and adult body composition in SRS are limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate body composition and metabolic health in adults with SRS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was an observational study of 25 individuals with molecularly confirmed SRS, aged \u2265\u202f18\u2005years, from research facilities across the UK. Body composition and metabolic health were assessed at a single appointment. Individuals with SRS were compared with unaffected men and women (from the Southampton Women's Survey [SWS]). Fat mass, lean mass, bone mineral density (BMD), blood pressure, lipids, and blood glucose were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-five adults with SRS were included (52% female). The median age was 32.9\u2005years (range, 22.0 to 69.7). Fat percentage was greater in the SRS group than the SWS cohort (44.1% vs 30.3%, P &amp;lt; .001). Fat mass index was similar (9.6 vs 7.8, P = .3). Lean mass percentage (51.8% vs 66.2%, P &amp;lt; .001) and lean mass index (13.5\u2005kg\/m2 vs 17.3\u2005kg\/m2, P &amp;lt; .001) were lower in the SRS group than the SWS cohort. BMD was lower in the SRS group than the SWS cohort (1.08 vs 1.24, P &amp;lt; .001; all median values). Total cholesterol was \u2265\u202f5\u2005mmol\/L in 52.0%. Triglyceride levels were \u2265\u202f1.7\u2005mmol\/L in 20.8%. Fasting blood glucose levels were \u2265\u202f6.1\u2005mmol\/L in 25.0%. Hypertension was present in 33.3%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Adults with SRS have an unfavorable body composition and predisposition to cardiometabolic disease. These results support the need for a health surveillance strategy to mitigate adverse outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae074","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T20:22:31Z","timestamp":1707423751000},"page":"e2001-e2008","source":"Crossref","is-referenced-by-count":10,"title":["Body Composition and Metabolism in Adults With Molecularly Confirmed Silver-Russell Syndrome"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8169-3384","authenticated-orcid":false,"given":"Oluwakemi","family":"Lokulo-Sodipe","sequence":"first","affiliation":[{"name":"Department of Human Development and Health, Faculty of Medicine, University of Southampton , Southampton, SO16 6YD ,","place":["UK"]},{"name":"Regional Paediatric Endocrinology Service, University Southampton Hospitals NHS Foundation Trust , Southampton, SO16 6YD 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SO16 6YD ,","place":["UK"]},{"name":"NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust , Southampton, SO16 6YD ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-8290","authenticated-orcid":false,"given":"Jenny","family":"Child","sequence":"additional","affiliation":[{"name":"Child Growth Foundation, c\/o Kinnair Associates Limited , Aston House, Newcastle, NE5 1NB , (affiliation at the time of this work)","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-0044","authenticated-orcid":false,"given":"Emma L","family":"Wakeling","sequence":"additional","affiliation":[{"name":"North East Thames Regional Genetic Service, Great Ormond Street Hospital for Children NHS Foundation Trust , London, WC1N 3JH 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