{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:35:22Z","timestamp":1769042122563,"version":"3.49.0"},"reference-count":23,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["64240267"],"award-info":[{"award-number":["64240267"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Research and Research Training Centre for Male Reproduction and Child Health","award":["1500321\/1604357"],"award-info":[{"award-number":["1500321\/1604357"]}]},{"name":"Candy Foundation","award":["2017-224 og 2020-344"],"award-info":[{"award-number":["2017-224 og 2020-344"]}]},{"name":"Absalon Foundation","award":["F-23653-01"],"award-info":[{"award-number":["F-23653-01"]}]},{"name":"the European Union\u2019s Horizon 2020","award":["733032 HBM4EU"],"award-info":[{"award-number":["733032 HBM4EU"]}]},{"DOI":"10.13039\/501100007036","name":"Danish Environmental Protection Agency","doi-asserted-by":"crossref","award":["MST-621-00012"],"award-info":[{"award-number":["MST-621-00012"]}],"id":[{"id":"10.13039\/501100007036","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005275","name":"Capital Region of Denmark","doi-asserted-by":"publisher","award":["E-22717-11"],"award-info":[{"award-number":["E-22717-11"]}],"id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Council of Rigshospitalet","award":["E-22717-12"],"award-info":[{"award-number":["E-22717-12"]}]},{"name":"Research Council of Rigshospitalet","award":["E-22717-07"],"award-info":[{"award-number":["E-22717-07"]}]},{"name":"Research Council of Rigshospitalet","award":["E-22717-08"],"award-info":[{"award-number":["E-22717-08"]}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","award":["10-001874"],"award-info":[{"award-number":["10-001874"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The hypothalamic-pituitary-gonadal axis's transient activity in infancy, i.e, minipuberty, is considered crucial for male reproductive function. Historically, minipuberty has been considered a passive response triggered by the withdrawal of placental steroids at birth. However, given its potential link to adult reproductive function, we hypothesize that minipuberty is a partially genetically regulated process, suggesting a link between the genetic architecture of reproductive hormone concentrations across lifespan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the association of UK Biobank Study-based polygenic scores (PGS) of adult total testosterone (T) and sex hormone-binding globulin (SHBG) concentrations with trajectories of reproductive hormones concentrations in male infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective, longitudinal birth cohort (The COPENHAGEN Minipuberty Study, 2016-2018, ClinTrial: NCT02784184). Individual PGSs in male infants derived from published literature were calculated for total T and SHBG. The associations with mean SD scores (SDS) of reproductive hormone concentrations in infancy were tested.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Population-based.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients or other participants<\/jats:title>\n                  <jats:p>Healthy, male, term, singleton newborns were followed with repeated clinical examinations including blood sampling during a 1-year follow-up (n = 109).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Circulating reproductive hormone concentrations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>T-PGSadult were significant associated with mean T-SDSinfancy, mean SHBG-SDSinfancy, and mean LH-SDSinfancy (P = .02, &amp;lt;.001 and .03, with r2 = 0.05, 0.21 and 0.04, respectively). SHBG-PGSadult was significantly associated with mean SHBG-SDSinfancy (P &amp;lt; .001, r2 = 0.18). T-PGSadult explained 5% and 21% of the phenotypic variation in infancy of mean T-SDSinfancy and SHBG-SDSinfancy, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings suggest that the genetic architecture underlying total T and SHBG in adults also associates with hormone concentrations and their trajectories during infancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae104","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T19:17:57Z","timestamp":1709061477000},"page":"2343-2348","source":"Crossref","is-referenced-by-count":2,"title":["Polygenic Scores for Adult Testosterone and SHBG Levels Are Associated With Reproductive Hormone Levels in Male Infants"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-569X","authenticated-orcid":false,"given":"Alexander Siegfried","family":"Busch","sequence":"first","affiliation":[{"name":"Department of General Pediatrics, University of M\u00fcnster , 48149 M\u00fcnster , Germany"},{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Lindhardt","family":"Ljubicic","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen , Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen , 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmie N","family":"Upners","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen , Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen , 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit Bistrup","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen , Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen , 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amadeusz","family":"Odroniec","sequence":"additional","affiliation":[{"name":"Department of General Pediatrics, University of M\u00fcnster , 48149 M\u00fcnster , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0250-8049","authenticated-orcid":false,"given":"Casper P","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen , Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen , 2100 Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0534-4350","authenticated-orcid":false,"given":"Anders","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen , Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction 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