{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:09:08Z","timestamp":1790874548311,"version":"4.1.0"},"reference-count":62,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016046","name":"Thelma Zo\u00e9gas Fond f\u00f6r Medicinsk forskning","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016046","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Thorsten Birger Segerfalks Stiftelse"},{"name":"Carl J Michaelsens Donationsfond"},{"name":"Anna-Lisa och Sven Eric Lundgrens stiftelse f\u00f6r medicinsk forskning"},{"name":"SUS stiftelser och donationer"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Contemporary patients with primary hyperparathyroidism are diagnosed with milder disease than previously. Clinical and biochemical factors predictors with an impact on fracture incidence and bone mineral density after surgery have not been firmly established.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate predictors of fracture incidence and bone mineral density preoperatively and after surgery for primary hyperparathyroidism (pHPT).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospectively collected surgical cohort with matched population controls. Data were cross-linked with the Swedish National Patient Register, the Prescribed Drug Register, and the Cause of Death Register.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Tertiary referral center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients or other participants<\/jats:title>\n                  <jats:p>Seven hundred nine patients with successful parathyroidectomy for pHPT and 2112 controls matched on sex, age, and municipality were included in the study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Fracture incidence, absolute change, and \u22652.77% increase in bone mineral density of femoral neck, L2\u2013L4, and distal third of radius at 1-year follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with pHPT had an increased fracture incidence before surgery but not after pHPT surgery. Fracture incidence after surgery was inversely related to preoperative 24-hour urine calcium (incidence rate ratio for the highest tertile 220\u2013 mg\/d 0.29, 95% confidence interval 0.11-0.73). Serum and 24-hour urine calcium, parathyroid hormone, osteocalcin, and adenoma weight were all associated with bone mineral density recovery after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Twenty-four-hour urine calcium is the most important biochemical variable to predict a decreased fracture incidence and improved bone mineral density after surgery for pHPT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae106","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T19:10:45Z","timestamp":1709061045000},"page":"e2273-e2282","source":"Crossref","is-referenced-by-count":9,"title":["24-hour Urine Calcium Predicts Reduced Fracture Incidence and Improved Bone Mineral Density After Surgery for Primary Hyperparathyroidism"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-0643","authenticated-orcid":false,"given":"Martin","family":"Nilsson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University , 221 84 Lund ,","place":["Sweden"]},{"name":"Department of Surgery, Sk\u00e5ne University Hospital , 221 85 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-2804","authenticated-orcid":false,"given":"Kristina E","family":"\u00c5kesson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , 202 13 Malm\u00f6 ,","place":["Sweden"]},{"name":"Department of Orthopedics, Sk\u00e5ne University Hospital , 205 02 Malm\u00f6 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-5357","authenticated-orcid":false,"given":"Mark","family":"Thier","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , 221 84 Lund ,","place":["Sweden"]},{"name":"Department of Surgery, Sk\u00e5ne University Hospital , 221 85 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6283-6917","authenticated-orcid":false,"given":"Erik","family":"Nordenstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , 221 84 Lund ,","place":["Sweden"]},{"name":"Department of Surgery, Sk\u00e5ne University Hospital , 221 85 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0953-1188","authenticated-orcid":false,"given":"Martin","family":"Almquist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , 221 84 Lund ,","place":["Sweden"]},{"name":"Department of Surgery, Sk\u00e5ne University Hospital , 221 85 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8355-6025","authenticated-orcid":false,"given":"Anders","family":"Bergenfelz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University , 221 84 Lund ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"issue":"6","key":"2024111804005262500_dgae106-B1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.beem.2018.09.001","article-title":"Classical complications of primary hyperparathyroidism","volume":"32","author":"Minisola","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"2","key":"2024111804005262500_dgae106-B2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrendo.2017.104","article-title":"Primary hyperparathyroidism","volume":"14","author":"Walker","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"2024111804005262500_dgae106-B3","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/oxfordjournals.aje.a114879","article-title":"Increased risk of malignant diseases after surgery for primary hyperparathyroidism. 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