{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:04:27Z","timestamp":1787321067566,"version":"build-2736575974"},"reference-count":51,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["A2022082"],"award-info":[{"award-number":["A2022082"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273631"],"award-info":[{"award-number":["82273631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SZXK065"],"award-info":[{"award-number":["SZXK065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Limited information was available on detailed associations of low-density lipoprotein cholesterol (LDL-C) with all-cause and cause-specific mortality in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included a representative sample of 211 290 adults aged 65 or older who participated in Shenzhen Healthy Aging Research 2018-2019. The vital status of the participants by December 31, 2021, was determined. We estimated the hazard ratios (HR) with 95% confidence intervals for all-cause or cause-specific mortality using multivariable Cox proportional hazards models and Cox models with restricted cubic spline (RCS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median follow-up time was 3.08 years. A total of 5333 participants were confirmed to have died. Among them, 2037 cardiovascular disease (CVD) deaths and 1881 cancer deaths occurred. Compared to those with LDL-C of 100 to 129\u2005mg\/dL, the all-cause mortality risk was significantly higher for individuals with LDL-C levels that were very low (&amp;lt;70\u2005mg\/dL) or low (70-99\u2005mg\/dL). Compared with individuals with the reference LDL-C level, the multivariable-adjusted HR for CVD-specific mortality was 1.338 for those with very low LDL-C levels (&amp;lt; 70\u2005mg\/dL), 1.437 for those with high LDL-C levels (160\u2005mg\/dL \u2264 LDL-C &amp;lt; 190\u2005mg\/dL), and 1.489 for those with very high LDL-C levels (\u2265190\u2005mg\/dL). Low LDL-C levels (70-99\u2005mg\/dL) and very low LDL-C levels (&amp;lt;70\u2005mg\/dL) were also associated with increased cancer mortality and other-cause mortality, respectively. The results from an RCS curve showed similar results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Considering the risk of all-cause mortality and cause-specific mortality, we recommended 100 to 159\u2005mg\/dL as the optimal range of LDL-C among older adults in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgae116","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T01:50:30Z","timestamp":1709257830000},"page":"e132-e139","source":"Crossref","is-referenced-by-count":8,"title":["Associations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China"],"prefix":"10.1210","volume":"110","author":[{"given":"Wenqing","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Elderly Health Management, Shenzhen Center for Chronic Disease Control , Shenzhen, Guangdong, 518020 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuebin","family":"Lv","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health, Chinese Center for Disease Control and Prevention , Bejing, 100021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Elderly Health Management, Shenzhen Center for Chronic Disease Control , Shenzhen, Guangdong, 518020 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Elderly Health Management, Shenzhen Center for Chronic Disease Control , Shenzhen, Guangdong, 518020 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Elderly Health Management, Shenzhen Center for Chronic Disease Control , Shenzhen, Guangdong, 518020 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Elderly Health Management, Shenzhen Center for Chronic Disease Control , Shenzhen, Guangdong, 518020 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-571X","authenticated-orcid":false,"given":"Xiaoming","family":"Shi","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health, Chinese Center for Disease Control and Prevention , Bejing, 100021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5727-8191","authenticated-orcid":false,"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Elderly Health Management, Shenzhen Center for Chronic Disease Control , Shenzhen, Guangdong, 518020 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"issue":"5","key":"2024121723514006700_dgae116-B1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jacc.2013.09.048","article-title":"AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of national cholesterol education program-adult treatment panel III low-density lipoprotein cholesterol goals among high-risk patients: an analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin thErapy-thrombolysis in myocardial infarction 57)","volume":"63","author":"Desai","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2024121723514006700_dgae116-B2","doi-asserted-by":"crossref","first-page":"e923722","DOI":"10.12659\/AJCR.923722","article-title":"Ineffective subtilisin\/kexin type 9 (PCSK9) inhibitors monotherapy in dyslipidemia with low-density lipoprotein cholesterol (LDL-C) receptor abnormalities: a report of 2 cases","volume":"21","author":"Matta","year":"2020","journal-title":"Am J Case Rep"},{"issue":"21","key":"2024121723514006700_dgae116-B3","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.jacc.2014.08.041","article-title":"Implications of the 2013 ACC\/AHA cholesterol guidelines for adults in contemporary cardiovascular practice: insights from the NCDR PINNACLE registry","volume":"64","author":"Maddox","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"2024121723514006700_dgae116-B4","first-page":"154","article-title":"Cholesterol and cardiovascular disease in the elderly. 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