{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:52Z","timestamp":1787021272142,"version":"build-2736575974"},"reference-count":25,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism (PHPT) is commonly diagnosed in the setting of hypercalcemia, whereas normocalcemic primary hyperparathyroidism (NHPT) may be misdiagnosed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our objective was to compare patients with hypercalcemic hyperparathyroidism (HPHPT) vs patients with NHPT hypercalciuric renal stones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We took advantage of a routine calcium load test performed in patients with hypercalciuric renal stones to assess retrospectively among patients with PHPT the prevalence and characteristics of NHPT and HPHPT under a calcium-restricted diet<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1671 patients with hypercalciuria, 91 patients had a final diagnosis of PHPT (postload ionized calcium [iCa] &amp;gt; 1.31\u2005mmol\/L and parathyroid hormone [PTH] &amp;gt; 30\u2005pg\/mL). Prevalence of NHPT is 40% of all PHPT; however, according to total serum calcium, 4\/35 NHPT and 7\/56 HPHPT cases would have been misclassified in the other group. Eighteen of 35 NHPT and 40\/56 HPHPT cases underwent parathyroidectomy. No significant characteristics relating to parathyroid weight, stone composition, or bone remodeling biomarkers were detected between groups. Although iCa is higher in HPHPT in the fasting state and after calcium load, we found no difference for calcium diet, 24-hour calciuria, or calcitriol. Renal calcium excretion postload increased by 303% in NHPT but only 176% in HPHPT (P = .01) likely explained by a lesser PTH decrease (P = .02). However, a strong negative association (P &amp;lt; .0001) detected between pooled preload and postload iCa and PTH only in the NHPT group suggests a persistent efficient PTH-CaSR control within the parathyroid glands in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data show the relevance of dynamic tests to unmask NHPT in patients with hypercalciuric renal stones.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgae162","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T03:40:10Z","timestamp":1710474010000},"page":"2553-2560","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of Normocalcemic vs Hypercalcemic Primary Hyperparathyroidism in a Hypercalciuric Renal Stone Population"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-3637","authenticated-orcid":false,"given":"Caroline","family":"Halimi","sequence":"first","affiliation":[{"name":"Service ORL et chirurgie cervico-faciale, H\u00f4pital Bichat, Assistance Publique-H\u00f4pitaux de Paris , 75018 Paris , France"},{"name":"INSERM, Unit\u00e9 mixte de Recherche 1155, Kidney Research Centre, AP-HP, H\u00f4pital Tenon, Sorbonne Universit\u00e9 , 75020 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemence","family":"Bor","sequence":"additional","affiliation":[{"name":"Service de Nephrologie, H\u00f4pital Europ\u00e9en de Paris , 93300 Aubervilliers , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Chieze","sequence":"additional","affiliation":[{"name":"Service d\u2019Explorations Fonctionnelles, H\u00f4pital Tenon, Assistance Publique-H\u00f4pitaux de Paris , 75020 Paris , 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m\u00e9decine nucl\u00e9aire, H\u00f4pital Tenon, Assistance Publique-H\u00f4pitaux de Paris , 75020 Paris , France"},{"name":"Institut National des Sciences et Techniques Nucl\u00e9aires (INSTN) , 91190 Saclay , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Montravers","sequence":"additional","affiliation":[{"name":"Service de m\u00e9decine nucl\u00e9aire, H\u00f4pital Tenon, Assistance Publique-H\u00f4pitaux de Paris , 75020 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Letavernier","sequence":"additional","affiliation":[{"name":"INSERM, Unit\u00e9 mixte de Recherche 1155, Kidney Research Centre, AP-HP, H\u00f4pital Tenon, Sorbonne Universit\u00e9 , 75020 Paris , France"},{"name":"Service d\u2019Explorations Fonctionnelles, H\u00f4pital Tenon, Assistance Publique-H\u00f4pitaux de Paris , 75020 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Buob","sequence":"additional","affiliation":[{"name":"INSERM, Unit\u00e9 mixte de Recherche 1155, Kidney Research Centre, AP-HP, H\u00f4pital Tenon, Sorbonne Universit\u00e9 , 75020 Paris , France"},{"name":"Service d\u2019anatomo-pathologie, H\u00f4pital Tenon, Assistance Publique-H\u00f4pitaux de Paris , 75020 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Daudon","sequence":"additional","affiliation":[{"name":"Service d\u2019Explorations Fonctionnelles, H\u00f4pital Tenon, Assistance Publique-H\u00f4pitaux de Paris , 75020 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Frochot","sequence":"additional","affiliation":[{"name":"INSERM, Unit\u00e9 mixte de Recherche 1155, Kidney Research Centre, AP-HP, H\u00f4pital Tenon, Sorbonne Universit\u00e9 , 75020 Paris , France"},{"name":"Service 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