{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:08:55Z","timestamp":1784257735263,"version":"3.55.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Serum calcium is frequently measured during the neonatal period, and it is known to be influenced by the vitamin D status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We hypothesized that the 25-hydroxyvitamin D (25OHD) concentration may influence the lower limit of the serum calcium normal range in neonates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included in our prospective cohort study 1002 mother-newborn pair recruited from April 2012 to July 2014, in 2 centers located in the neighborhoods of Paris, France, whose serum calcium was measured at 3 days of life. We established, after exclusion of outliers, a 95% CI for serum calcium (i) in our whole population of 1002 neonates; (ii) in neonates with a cord blood 25OHD concentration \u2265 30\u2005nmol\/L; and (iii) in those with a 25OHD \u2265 50\u2005nmol\/L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean serum total calcium was 2.46 \u00b1 0.13\u2005nmol\/L (95% CI: 2.19-2.72\u2005mmol\/L), 2.47 \u00b1 0.25\u2005mmol\/L (95% CI: 2.22-2.72\u2005mmol\/L), and 2.50 \u00b1 0.25\u2005mmol\/L (95% CI: 2.25-2.75\u2005mmol\/L) in the whole group, in the 514 neonates with 25OHD \u2265 30\u2005nmol\/L, and in the 202 neonates with 25OHD \u2265 50\u2005nmol\/L respectively. The lower limit of the 95% range was significantly higher in neonates with 25 OHD \u2265 30\u2005nmol\/L (P &amp;lt; 0.05) and \u2265 50\u2005nmol\/L (P &amp;lt; .001) than in the entire cohort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We show that the lower limit of the normal serum calcium range is higher in groups with a higher 25OHD than in unselected subjects. We propose that the reference range for serum calcium in neonates is 2.25 to 2.75\u2005mmol\/L.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae167","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:39:38Z","timestamp":1710340778000},"page":"e68-e71","source":"Crossref","is-referenced-by-count":3,"title":["Reference Values for Serum Calcium in Neonates Should Be Established in a Population of Vitamin D\u2013Replete Subjects"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4953-6933","authenticated-orcid":false,"given":"Lucie","family":"Levaillant","sequence":"first","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence des maladies rares du m\u00e9tabolisme du calcium et du phosphate, AP-HP, H\u00f4pital Bic\u00eatre Paris-Saclay, service d\u2019endocrinologie et diab\u00e8te de l\u2019enfant, fili\u00e8re OSCAR, DMU 3 SEA , 94270 Le Kremlin-Bic\u00eatre ,","place":["France"]},{"name":"Department of Pediatric Endocrinology and Diabetology, University Hospital of Angers , 49933 Angers Cedex 9 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-002X","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Linglart","sequence":"additional","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence des maladies rares du m\u00e9tabolisme du calcium et du phosphate, AP-HP, H\u00f4pital Bic\u00eatre Paris-Saclay, service d\u2019endocrinologie et diab\u00e8te de l\u2019enfant, fili\u00e8re OSCAR, DMU 3 SEA , 94270 Le Kremlin-Bic\u00eatre ,","place":["France"]},{"name":"Universit\u00e9 Paris Saclay, INSERM, physiologie et physiopathologie endocrinienne , 94270 Le Kremlin-Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Gajdos","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pital Antoine B\u00e9cl\u00e8re, service de p\u00e9diatrie, DMU3 SEA , 92140 Clamart ,","place":["France"]},{"name":"Universit\u00e9 Paris-Saclay, INSERM, CESP Centre for Research in Epidemiology and Population Health , 94800 Villejuif ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Benachi","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pital Antoine B\u00e9cl\u00e8re, service de gyn\u00e9cologie-obst\u00e9trique, DMU2 Sant\u00e9 des Femmes et des nouveau-n\u00e9s , 92140 Clamart ,","place":["France"]},{"name":"Universit\u00e9 Paris-Saclay , 94270 Le Kremlin-Bic\u00eatre ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Souberbielle","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pital Necker-Enfants Malades, Explorations Fonctionnelles , 75015 Paris 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