{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:15:43Z","timestamp":1772579743333,"version":"3.50.1"},"reference-count":68,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Hyponatremia is associated with increased risk of osteoporosis and fractures. The impact of hyponatremia on noninvasive indices of bone quality, however, is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate whether trabecular bone microarchitecture, assessed noninvasively by trabecular bone score (TBS), is altered in patients with hyponatremia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a cross-sectional analysis of the population-based 2005-2008 cycles of the National Health and Nutrition Examination Survey, in which TBS measurement was performed. The main outcome measures were TBS values and bone mineral density (BMD) T-scores at the lumbar spine, total hip and femoral neck.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 4204 subjects aged 50 years or older were included (4041 normonatremic, 163 hyponatremic\u201490.8% with mild hyponatremia). Univariate analyses did not show any difference in TBS between patients with and without hyponatremia (1.308 \u00b1 0.145 vs 1.311 \u00b1 0.141, P = .806). Hyponatremic subjects had lower BMD T-score at total hip (\u22120.70 \u00b1 1.46 vs \u22120.13 \u00b1 1.32, P &amp;lt; .001) and femoral neck (\u22121.11 \u00b1 1.26 vs \u22120.72 \u00b1 1.14, P = .004), while no difference was observed at lumbar spine (\u22120.27 \u00b1 1.63 vs \u22120.31 \u00b1 1.51, P = .772). After adjustment for relevant confounders, hyponatremia was confirmed as an independent predictor of lower BMD T-score at the total hip (\u03b2 = \u22120.20, 95% confidence interval [CI]: [\u22120.39, \u22120.02], P = .029), while the significance was lost at the femoral neck (P = .308). Again, no association between hyponatremia and lumbar spine BMD (P = .236) or TBS (P = .346) was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Hyponatremia, at least in mild forms, is not associated with a degradation of trabecular microarchitecture, assessed noninvasively by TBS. An independent association between hyponatremia and loss of bone mass is confirmed, particularly at the total hip.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae234","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T08:41:25Z","timestamp":1712738485000},"page":"e774-e782","source":"Crossref","is-referenced-by-count":7,"title":["Mild Hyponatremia Is Not Associated With Degradation of Trabecular Bone Microarchitecture Despite Bone Mass Loss"],"prefix":"10.1210","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-7023","authenticated-orcid":false,"given":"Fabio","family":"Bioletto","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Sibilla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Maria","family":"Berton","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunzia","family":"Prencipe","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-8586","authenticated-orcid":false,"given":"Emanuele","family":"Varaldo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Maiorino","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Cuboni","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Pusterla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Gasco","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Grottoli","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezio","family":"Ghigo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Arvat","sequence":"additional","affiliation":[{"name":"Division of Oncological Endocrinology, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Procopio","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin , Turin, 10126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Barale","sequence":"additional","affiliation":[{"name":"Division of Oncological Endocrinology, Department of Medical Sciences, University of Turin , Turin, 10126 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