{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:06:07Z","timestamp":1787162767791,"version":"build-2736575974"},"reference-count":16,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072804"],"award-info":[{"award-number":["82072804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical features, imaging characteristics, and molecular profile of sellar neurocytoma (SN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical, imaging, and pathological features of 11 cases of SN were retrospectively analyzed. Electron microscopy was performed in 5 cases. Molecular features were detected in tumor tissue by RNA sequencing, quantitative polymerase chain reaction, and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The clinical features of SN patients showed a high incidence of hyponatremia (73%, 8\/11), and the tumors tended to invade the lateral side of the saddle area from preoperative imaging analysis. The tumors had positive NeuN, synaptophysin, neurofilament, somatostatin receptor 2 (SSTR2) immunohistochemistry staining. Tumor transcriptomic analysis suggested a new LMCD1-AS1:GRM7-AS1 fusion gene event and increased expression of 10 hypothalamus-secreted hormones in SN. Fifteen differentially expressed genes were verified for quantitative polymerase chain reaction verification. SSTR2 has been verified by immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hyponatremia is the dominant clinical features of SN. Preoperative imaging suggests that growth toward the dorsal region is the imaging feature of SN. SSTR2 expression and LMCD1-AS1:GRM7-AS1 fusion gene event expected to become a new molecular marker for SN. Somatostatin receptor ligand therapy may be a potential therapy for SN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgae260","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T19:21:12Z","timestamp":1713208872000},"page":"e710-e716","source":"Crossref","is-referenced-by-count":3,"title":["Clinicopathological and Molecular Profile of Sellar Neurocytoma"],"prefix":"10.1210","volume":"110","author":[{"given":"Yulou","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Cheng","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Fang","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyan","family":"Xie","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0256-1261","authenticated-orcid":false,"given":"Chuzhong","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Neurosurgical Institute, Capital Medical University , Beijing 100070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"2025021815510468300_dgae260-B1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jocn.2022.03.038","article-title":"Extraventricular neurocytoma at the sellar region: report of 8 cases and literature review","volume":"99","author":"Zhao","year":"2022","journal-title":"J Clin Neurosci"},{"issue":"2","key":"2025021815510468300_dgae260-B2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/PAS.0000000000001185","article-title":"Hypothalamic vasopressin-producing tumors: often inappropriate diuresis but occasionally Cushing disease","volume":"43","author":"Asa","year":"2019","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"2025021815510468300_dgae260-B3","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1186\/s40064-016-2650-2","article-title":"Extraventricular neurocytoma of the sellar region: case report and literature review","volume":"5","author":"Wang","year":"2016","journal-title":"Springerplus"},{"key":"2025021815510468300_dgae260-B4","doi-asserted-by":"crossref","first-page":"861540","DOI":"10.3389\/fendo.2022.861540","article-title":"A clinicopathological and molecular analysis of sellar\/suprasellar neurocytoma mimicking pituitary adenoma","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"2025021815510468300_dgae260-B5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11060-018-2952-z","article-title":"Imaging characteristics of cerebral extraventricular neurocytoma with pathological correlation","volume":"140","author":"Jiang","year":"2018","journal-title":"J Neurooncol"},{"issue":"2","key":"2025021815510468300_dgae260-B6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF02921349","article-title":"Hypothalamic neurocytoma with vasopressin immunoreactivity: immunohistochemical and ultrastructural observations","volume":"3","author":"Maguire","year":"1992","journal-title":"Endocr Pathol"},{"issue":"2","key":"2025021815510468300_dgae260-B7","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00401-018-1882-3","article-title":"FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma","volume":"136","author":"Sievers","year":"2018","journal-title":"Acta Neuropathol"},{"key":"2025021815510468300_dgae260-B8","doi-asserted-by":"crossref","unstructured":"Liu Y, Guo J, Cheng J, et al \u00a0Supplement materials for \u201cClinicopathological and molecular profile of sellar neurocytoma\u201d. 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