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Recent data suggest that transitional hypoglycemia is due to persistence of the fetal beta cell's lower threshold for insulin release, resulting in a transient hyperinsulinemic state. While hypoglycemia is an expected part of the transition to postnatal life, it makes the identification of infants with persistent hypoglycemia disorders challenging. Given the risk of neurologic injury from hypoglycemia, identifying these infants is critical. Hyperinsulinism is the most common cause of persistent hypoglycemia in neonates and infants and carries a high risk of neurocognitive dysfunction given the severity of the hypoglycemia and the inability to generate ketones, a critical alternative cerebral fuel. Screening neonates at risk for persistent hypoglycemia disorders and completing evaluations prior to hospital discharge is essential to prevent delayed diagnoses and neurologic damage.<\/jats:p>","DOI":"10.1210\/clinem\/dgae267","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T19:08:08Z","timestamp":1713380888000},"page":"e1787-e1795","source":"Crossref","is-referenced-by-count":6,"title":["Approach to the Neonate With Hypoglycemia"],"prefix":"10.1210","volume":"109","author":[{"given":"Katherine","family":"Lord","sequence":"first","affiliation":[{"name":"The Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia , Philadelphia, PA 19104 , USA"},{"name":"Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania , Philadelphia, PA 19104 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1225-8087","authenticated-orcid":false,"given":"Diva 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