{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:09:55Z","timestamp":1791346195738,"version":"4.3.1"},"reference-count":42,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870537"],"award-info":[{"award-number":["81870537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070816"],"award-info":[{"award-number":["82070816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170802"],"award-info":[{"award-number":["82170802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200874"],"award-info":[{"award-number":["82200874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270826"],"award-info":[{"award-number":["82270826"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300879"],"award-info":[{"award-number":["82300879"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20161318"],"award-info":[{"award-number":["20161318"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-Level Local Universities in Shanghai","doi-asserted-by":"publisher","award":["SHSMU-ZDCX20210901"],"award-info":[{"award-number":["SHSMU-ZDCX20210901"]}],"id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-Level Local Universities in Shanghai","doi-asserted-by":"publisher","award":["SHSMU-ZDCX20212501"],"award-info":[{"award-number":["SHSMU-ZDCX20212501"]}],"id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Shanghai","award":["22ZR1436600"],"award-info":[{"award-number":["22ZR1436600"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Congenital hypothyroidism (CH) is the most common endocrine disorder in neonates, but its etiology is still poorly understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We performed whole exome sequencing to identify a novel causative gene for CH and functional studies to validate its role in the occurrence of CH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Whole exome sequencing in 98 CH patients not harboring known CH candidate genes and bioinformatic analysis were performed. Functional analysis was performed using morpholino, a synthetic short antisense oligonucleotide that contains 25 DNA bases on a methylene morpholine backbone, in zebrafish and CRISPR-Cas9-mediated gene knockout in mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eukaryotic translation initiation factor 4B (EIF4B) was identified as the most promising candidate gene. The EIF4B gene was inherited in an autosomal recessive model, and 1 patient with thyroid dysgenesis carried EIF4B biallelic variants (p.S430F\/p.P328L). In zebrafish, the knockdown of eif4ba\/b expression caused thyroid dysgenesis and growth retardation. Thyroid hormone levels were significantly decreased in morphants compared with controls. Thyroxine treatment in morphants partially rescued growth retardation. In mice, the homozygous conceptuses of Eif4b+\/\u2212 parents did not survive. Eif4b knockout embryos showed severe growth retardation, including thyroid dysgenesis and embryonic lethality before E18.5.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These experimental data support a role for EIF4B function in the pathogenesis of the hypothyroid phenotype seen in CH patients. Our work indicates that EIF4B was identified as a novel candidate gene in CH. EIF4B is essential for animal survival, but further studies are needed to validate its role in the pathogenesis of CH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae270","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T08:23:29Z","timestamp":1713774209000},"page":"3282-3292","source":"Crossref","is-referenced-by-count":9,"title":["Identification of Eukaryotic Translation Initiation Factor 4B as a Novel Candidate Gene for Congenital Hypothyroidism"],"prefix":"10.1210","volume":"109","author":[{"given":"Feng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Jia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]},{"name":"Department of Endocrinology and Metabolism, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University , Suzhou, Jiangsu, 215000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Run","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Yao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Meng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9609-5803","authenticated-orcid":false,"given":"Huai-Dong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-9541","authenticated-orcid":false,"given":"Shuang-Xia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, The Core Laboratory in Medical Center of Clinical Research, Department of Endocrinology, Shanghai Ninth People's Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine , Shanghai 200011 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"issue":"3","key":"2024111804025765100_dgae270-B1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/ijns7030034","article-title":"Newborn screening for congenital hypothyroidism in Japan","volume":"7","author":"Minamitani","year":"2021","journal-title":"Int J Neonatal Screen"},{"issue":"18","key":"2024111804025765100_dgae270-B2","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1097\/CM9.0000000000001613","article-title":"Geographic variations in the incidence of congenital hypothyroidism in China: a retrospective study based on 92 million newborns screened in 2013\u20132018","volume":"134","author":"Yao","year":"2021","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"2024111804025765100_dgae270-B3","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1210\/jc.2012-3273","article-title":"Congenital hypothyroidism due to defects of thyroid development and mild increase of TSH at screening: data from the Italian national registry of infants with congenital hypothyroidism","volume":"98","author":"Olivieri","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024111804025765100_dgae270-B4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1051\/medsci\/2022028","article-title":"[Genetic of congenital hypothyroidism]","volume":"38","author":"Stoupa","year":"2022","journal-title":"Med Sci (Paris)"},{"issue":"5","key":"2024111804025765100_dgae270-B5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/jmg.2004.024158","article-title":"Genetics of congenital hypothyroidism","volume":"42","author":"Park","year":"2005","journal-title":"J Med Genet"},{"issue":"6","key":"2024111804025765100_dgae270-B6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1530\/EJE-17-1017","article-title":"The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes","volume":"178","author":"Sun","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2024111804025765100_dgae270-B7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41574-019-0184-8","article-title":"The role of thyroglobulin in thyroid hormonogenesis","volume":"15","author":"Citterio","year":"2019","journal-title":"Nat Rev Endocrinol"},{"issue":"20","key":"2024111804025765100_dgae270-B8","doi-asserted-by":"crossref","first-page":"e99631","DOI":"10.1172\/jci.insight.99631","article-title":"Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism","volume":"3","author":"Cangul","year":"2018","journal-title":"JCI Insight"},{"issue":"1","key":"2024111804025765100_dgae270-B9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/cge.13627","article-title":"Molecular defects in thyroid dysgenesis","volume":"97","author":"Mio","year":"2020","journal-title":"Clin Genet"},{"issue":"12","key":"2024111804025765100_dgae270-B10","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1172\/JCI94417","article-title":"GLIS3 is indispensable for TSH\/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation","volume":"127","author":"Kang","year":"2017","journal-title":"J Clin Invest"},{"issue":"3","key":"2024111804025765100_dgae270-B11","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jc.2015-3403","article-title":"JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects","volume":"101","author":"de Filippis","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024111804025765100_dgae270-B12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1210\/en.2014-1628","article-title":"Functional zebrafish studies based on human genotyping point to netrin-1 as a link between aberrant cardiovascular development and thyroid dysgenesis","volume":"156","author":"Opitz","year":"2015","journal-title":"Endocrinology"},{"issue":"3","key":"2024111804025765100_dgae270-B13","first-page":"599","article-title":"Mutations in BOREALIN cause thyroid dysgenesis","volume":"26","author":"Carr\u00e9","year":"2016","journal-title":"Hum Mol Genet"},{"issue":"12","key":"2024111804025765100_dgae270-B14","doi-asserted-by":"crossref","first-page":"e9569","DOI":"10.15252\/emmm.201809569","article-title":"TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology","volume":"10","author":"Stoupa","year":"2018","journal-title":"EMBO Mol Med"},{"issue":"1","key":"2024111804025765100_dgae270-B15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000507114","article-title":"Identification of transient receptor potential channel 4-associated protein as a novel candidate gene causing congenital primary hypothyroidism","volume":"93","author":"Choukair","year":"2020","journal-title":"Horm Res Paediatr"},{"issue":"10","key":"2024111804025765100_dgae270-B16","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1038\/s41436-021-01237-3","article-title":"Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis","volume":"23","author":"Yang","year":"2021","journal-title":"Genet Med"},{"key":"2024111804025765100_dgae270-B17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cca.2017.04.020","article-title":"Next-generation sequencing of NKX2.1, FOXE1, PAX8, NKX2.5, and TSHR in 100 Chinese patients with congenital hypothyroidism and athyreosis","volume":"470","author":"Wang","year":"2017","journal-title":"Clin Chim Acta"},{"issue":"10","key":"2024111804025765100_dgae270-B18","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1507\/endocrj.EJ18-0156","article-title":"Targeted next-generation sequencing of thirteen causative genes in Chinese patients with congenital hypothyroidism","volume":"65","author":"Long","year":"2018","journal-title":"Endocr J"},{"issue":"5","key":"2024111804025765100_dgae270-B19","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1210\/er.2003-0028","article-title":"Thyroid development and its disorders: genetics and molecular mechanisms","volume":"25","author":"De Felice","year":"2004","journal-title":"Endocr Rev"},{"issue":"3","key":"2024111804025765100_dgae270-B20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1051\/medsci\/2022028","article-title":"Genetic of congenital hypothyroidism","volume":"38","author":"Stoupa","year":"2022","journal-title":"Med Sci (Paris)"},{"issue":"9","key":"2024111804025765100_dgae270-B21","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1002\/j.1460-2075.1990.tb07466.x","article-title":"Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif","volume":"9","author":"Milburn SC","year":"1990","journal-title":"EMBO J"},{"issue":"12","key":"2024111804025765100_dgae270-B22","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1038\/sj.emboj.7601166","article-title":"The mTOR\/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity","volume":"25","author":"Shahbazian","year":"2006","journal-title":"EMBO J"},{"issue":"1","key":"2024111804025765100_dgae270-B23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/onc.2008.367","article-title":"AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B","volume":"28","author":"van Gorp","year":"2009","journal-title":"Oncogene"},{"issue":"1","key":"2024111804025765100_dgae270-B24","doi-asserted-by":"crossref","first-page":"10563","DOI":"10.1038\/s41598-017-11096-1","article-title":"eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology","volume":"7","author":"Bettegazzi","year":"2017","journal-title":"Sci Rep"},{"issue":"8","key":"2024111804025765100_dgae270-B25","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/sj.emboj.7600193","article-title":"Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases","volume":"23","author":"Raught","year":"2004","journal-title":"EMBO J"},{"issue":"1","key":"2024111804025765100_dgae270-B26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13073-019-0690-2","article-title":"Recommendations for application of the functional evidence PS3\/BS3 criterion using the ACMG\/AMP sequence variant interpretation framework","volume":"12","author":"Brnich","year":"2019","journal-title":"Genome Med"},{"issue":"5","key":"2024111804025765100_dgae270-B27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American college of medical genetics and genomics and the association for molecular pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2024111804025765100_dgae270-B28","unstructured":"Sun F, Zhang RJ, Fang Y, et al Supplementary material for \u201cIdentification of eukaryotic translation initiation factor 4B as a novel candidate gene for congenital hypothyroidism\u201d. Figshare. 2004. 10.6084\/m9.figshare.25522849"},{"issue":"3","key":"2024111804025765100_dgae270-B29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev Dyn"},{"issue":"8","key":"2024111804025765100_dgae270-B30","doi-asserted-by":"crossref","first-page":"bqab101","DOI":"10.1210\/endocr\/bqab101","article-title":"Genetic manipulation on zebrafish duox recapitulate the clinical manifestations of congenital hypothyroidism","volume":"162","author":"Sun","year":"2021","journal-title":"Endocrinology"},{"issue":"4","key":"2024111804025765100_dgae270-B31","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1210\/jc.2009-2373","article-title":"Transcription factor mutations and congenital hypothyroidism: systematic genetic screening of a population-based cohort of Japanese patients","volume":"95","author":"Narumi","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024111804025765100_dgae270-B32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1297\/cpe.2022-0016","article-title":"Knowns and unknowns about congenital hypothyroidism: 2022 update","volume":"32","author":"Itonaga","year":"2023","journal-title":"Clin Pediatr Endocrinol"},{"issue":"5","key":"2024111804025765100_dgae270-B33","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/humrep\/deaa049","article-title":"Thyroid function in neonates conceived after hysterosalpingography with iodinated contrast","volume":"35","author":"Mijatovic","year":"2020","journal-title":"Hum Reprod"},{"issue":"6","key":"2024111804025765100_dgae270-B34","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1542\/peds.2014-0900","article-title":"Iodine deficiency, pollutant chemicals, and the thyroid: new information on an old problem","volume":"133","author":"Rogan","year":"2014","journal-title":"Pediatrics"},{"key":"2024111804025765100_dgae270-B35","doi-asserted-by":"crossref","first-page":"723885","DOI":"10.3389\/fimmu.2021.723885","article-title":"Deficiency of eIF4B increases mouse mortality and impairs antiviral immunity","volume":"12","author":"Chen","year":"2021","journal-title":"Front Immunol"},{"issue":"15","key":"2024111804025765100_dgae270-B36","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1158\/0008-5472.CAN-12-4277","article-title":"eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes","volume":"73","author":"Yang","year":"2013","journal-title":"Cancer Res"},{"issue":"1","key":"2024111804025765100_dgae270-B37","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/s41467-018-03028-y","article-title":"Fatty acid synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL","volume":"9","author":"Kapadia","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"2024111804025765100_dgae270-B38","doi-asserted-by":"crossref","first-page":"e1603","DOI":"10.1038\/cddis.2014.542","article-title":"The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape","volume":"6","author":"Modelska","year":"2015","journal-title":"Cell Death Dis"},{"key":"2024111804025765100_dgae270-B39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejca.2017.06.003","article-title":"New liver cancer biomarkers: PI3K\/AKT\/mTOR pathway members and eukaryotic translation initiation factors","volume":"83","author":"Golob-Schwarzl","year":"2017","journal-title":"Eur J Cancer"},{"issue":"2","key":"2024111804025765100_dgae270-B40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/157340611794859325","article-title":"Interaction of mesalasine (5-ASA) with translational initiation factors eIF4 partially explains 5-ASA anti-inflammatory and anti-neoplastic activities","volume":"7","author":"Lyakhovich","year":"2011","journal-title":"Med Chem"},{"issue":"38","key":"2024111804025765100_dgae270-B41","doi-asserted-by":"crossref","first-page":"10464","DOI":"10.1073\/pnas.1612398113","article-title":"eIF4B stimulates translation of long mRNAs with structured 5\u2032 UTRs and low closed-loop potential but weak dependence on eIF4G","volume":"113","author":"Sen","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2024111804025765100_dgae270-B42","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.18632\/aging.204567","article-title":"A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B\/YRDC axis","volume":"15","author":"Gong","year":"2023","journal-title":"Aging (Albany NY)"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgae270\/57466118\/dgae270.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/109\/12\/3282\/60680486\/dgae270.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/109\/12\/3282\/60680486\/dgae270.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T04:04:08Z","timestamp":1731902648000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/109\/12\/3282\/7657055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":42,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,4,24]]},"published-print":{"date-parts":[[2024,11,18]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgae270","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,4,24]]}}}